{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:02:17Z","timestamp":1773032537318,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Spontaneous bacterial peritonitis (SBP) is common in decompensated cirrhosis and often accompanied by large volume ascites. However, the safety of early therapeutic paracentesis is unknown and may lead to unnecessary delay in procedural performance. We aimed to assess whether paracentesis performance characteristics in the setting of SBP influenced renal or circulatory outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center, retrospective cohort study was performed involving adult patients diagnosed with SBP based on ascites fluid studies during index admission between 2010 and 2020. Patient and procedural characteristics were collected and analyzed with respect to paracentesis timing (early vs. delayed) and volume (diagnostic only vs. non\u2010large volume therapeutic vs. large volume therapeutic). The primary outcome was a composite of the development of AKI and\/or circulatory dysfunction. Secondary outcomes included 30\u2010day mortality, 90\u2010day mortality, and change in baseline renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One\u2010hundred forty\u2010four patients met inclusion criteria during the study timeframe (Child\u2010Pugh C 74%, mean MELD\u2010Na 25). Sixty\u2010six (46%) met ACLF criteria at the time of SBP diagnosis. One\u2010hundred eight (75%) patients underwent a therapeutic paracentesis, of which approximately two\u2010thirds were performed within 24\u2009h of admission (early); 41% were large volume (\u2265\u20095\u2009L of ascites removed). There was no difference in rates of the primary outcome with respect to either paracentesis timing or volume. Short\u2010term mortality and change in baseline renal function were independent of procedural characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Therapeutic paracentesis does not appear to induce renal or circulatory dysfunction in patients with SBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70339","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:12:17Z","timestamp":1770959537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance of Early Therapeutic Paracentesis in Spontaneous Bacterial Peritonitis and Its Effect on Clinical Outcomes"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-887X","authenticated-orcid":false,"given":"Brian J.","family":"Wentworth","sequence":"first","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology, Department of Medicine, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Shwetar","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-5728","authenticated-orcid":false,"given":"Indika","family":"Mallawaarachchi","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Public Health Sciences, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Public Health Sciences, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-7134","authenticated-orcid":false,"given":"Mary","family":"McGrath","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4987-526X","authenticated-orcid":false,"given":"Laura","family":"Lavette","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Rainho","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology, Department of Medicine, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeral","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology, Department of Medicine, School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.08.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001578"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2008.02.016"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S164250"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.212"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31884"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2019-101199"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.012"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.042"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840020402"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120415"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22853"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.029"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4140-3"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.1.2.125"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908053410603"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.05.014"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-018-9853-2"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230122"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2019.83157"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2015.21.4.365"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-2-S1-S4"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251498"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04938-8"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000671"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.09.016"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.03.005"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26359"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.70339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:11:00Z","timestamp":1773029460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jgh3.70339"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70339","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70339"}}