{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:22:35Z","timestamp":1783426955292,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Proton pump inhibitors (PPIs) and potassium\u2010competitive acid blockers (PCABs) are widely used for acid\u2010related disorders. Recent studies have raised concerns that acid suppression may alter gut microbiota and drug pharmacokinetics, potentially influencing therapeutic outcomes in patients with inflammatory bowel disease. However, the impact of PPI\/PCAB use on oral 5\u2010aminosalicylic acid (5\u2010ASA) therapy and intolerance in ulcerative colitis (UC) remains unclear. We aimed to examine whether concomitant PPI\/PCAB use was associated with 5\u2010ASA discontinuation and intolerance in patients with UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed consecutive patients who received oral 5\u2010ASA for the first time between 2015 and 2022 at a single tertiary center. Patients receiving concomitant steroids or cytapheresis at baseline were excluded. The primary outcome was the association between PPI\/PCAB use and 5\u2010ASA intolerance, and the secondary outcome was the association with treatment discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 181 patients were included in this study. The cumulative continuation rates of oral 5\u2010ASA at 1, 3, and 5\u2009years were 60.4%, 45.4%, and 39.3%, respectively. Overall, 29 patients (16.0%) developed 5\u2010ASA intolerance. In multivariate analyses, concomitant PPI\/PCAB use was independently associated with 5\u2010ASA intolerance (OR 9.65, 95% CI 1.92\u201348.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and treatment discontinuation (HR 2.46, 95% CI 1.06\u20135.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), whereas age\u2009\u2265\u200940\u2009years was associated with lower odds of intolerance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Concomitant PPI\/PCAB use was associated with higher rates of 5\u2010ASA discontinuation and intolerance in patients with UC. These findings suggest novel associations and warrant validation in larger, prospective cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70350","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:25:04Z","timestamp":1769923504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Proton Pump Inhibitor and Potassium\u2010Competitive Acid Blocker Use With Discontinuation and Intolerance of Oral 5\u2010Aminosalicylic Acid in Patients With Ulcerative Colitis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-9334","authenticated-orcid":false,"given":"Shinsuke","family":"Otagiri","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Center Sapporo Higashi Tokushukai Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-4840","authenticated-orcid":false,"given":"Takahiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Sapporo Higashi Tokushukai Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Yagisawa","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Sapporo Higashi Tokushukai Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumu","family":"Sugitani","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Sapporo Higashi Tokushukai Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Maemoto","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Sapporo Higashi Tokushukai Hospital  Sapporo Hokkaido 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