{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:02:22Z","timestamp":1773032542308,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Optimal steroid induction therapy in autoimmune hepatitis (AIH) is unclear. We aimed to investigate the relationship between steroid dosing, route of administration, and time to biochemical response to help standardize AIH practice patterns and reduce excess steroid exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective cohort study of adult patients with non\u2010severe AIH receiving induction steroid therapy. Patients were stratified into three treatment groups: (1) low\u2010dose oral steroids (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939; prednisone &lt;\u200940\u2009mg\/day or budesonide 9\u2009mg\/day), (2) high\u2010dose oral steroids (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932; prednisone 40\u2009mg\/day), and (3) intravenous steroids (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921; methylprednisolone 1\u2009g\/day). Time to biochemical response and predictors of biochemical response were compared at 6\u2010 and 12\u2010month intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rates of biochemical response were similar between the low\u2010 and high\u2010dose oral steroid groups at 6\u2009months (72% vs. 78%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.54) and 12\u2009months (92% vs. 91%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00). Regarding high\u2010dose oral versus IV steroid induction, rates of biochemical response were similar between groups at 6\u2009months (78% vs. 86%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.72) and 12\u2009months (91% vs. 90%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00). Time to biochemical response was not significantly different across all groups at both 6 and 12\u2009months (log\u2010rank test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.23 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.42, respectively). Initial biomarkers of disease severity were not predictive of time to biochemical response across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower dose prednisone may be an effective initial induction regimen in outpatients with AIH. Similarly, oral steroids may be non\u2010inferior to IV steroids. Together, these results favor a more conservative approach for non\u2010severe AIH induction therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70371","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:36:59Z","timestamp":1772966219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosing and Route of Steroid Induction Therapy in Non\u2010Severe Autoimmune Hepatitis Do Not Affect Time to Biochemical Response"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4987-526X","authenticated-orcid":false,"given":"Laura E.","family":"Lavette","sequence":"first","affiliation":[{"name":"Department of Medicine University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-7134","authenticated-orcid":false,"given":"Mary S.","family":"McGrath","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew K.","family":"Schliep","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor M.","family":"Horgan","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Sridharan","sequence":"additional","affiliation":[{"name":"Department of Medicine Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-887X","authenticated-orcid":false,"given":"Brian J.","family":"Wentworth","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23584"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100149"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31065"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.03.017"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.012"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.11.032"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13252"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21787"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24141"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.041"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.qjmed.a067264"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(19)33223\u20108"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(73)92125\u20109"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.1.78"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000589"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.7874\/kja.2012.16.2.65"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/87551225221116266"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.12.035"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010017\u20104728\u20102"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.046"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26290"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2024.101149"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13907"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618768922"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018313"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12582"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.03.021"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080414"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510123331502"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i33.6030"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2023.2287100"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2021.06.009"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188644"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.021"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.70371","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:11:02Z","timestamp":1773029462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jgh3.70371"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70371","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70371"}}