{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:02:41Z","timestamp":1783742561926,"version":"3.55.0"},"reference-count":82,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gastroparesis is a sensorimotor condition characterized by delayed gastric emptying without any obvious mechanical obstruction. Common symptoms include early satiety, nausea, vomiting, belching, and bloating. The most frequent causes of gastroparesis are diabetes, idiopathic factors, and post\u2010surgical complications. Currently, the only FDA\u2010approved medication for treating gastroparesis is metoclopramide; however, due to its potential side effects, particularly extrapyramidal symptoms, there is increasing interest in safer, more tolerable alternatives, such as prokinetics, antiemetics, and fundic relaxants. Recent advancements in pharmacological agents have demonstrated variable efficacy in improving gastric emptying and gastroparesis\u2010related symptoms, although symptom improvement does not consistently correlate with changes in gastric emptying metrics. In addition to pharmacological treatments, non\u2010pharmacological approaches like gastric peroral endoscopic myotomy (G\u2010POEM) and neuromodulation techniques have demonstrated significant improvements in symptoms and gastric emptying. The current understanding of gastroparesis care is still limited, and the best practices in treatment remain uncertain. Future research should prioritize multicenter trials that involve large patient populations to explore emerging therapies and innovative techniques. In this review, we will discuss the existing standards of care, advancements in novel pharmacological, interventional, and neuromodulatory treatments for gastroparesis, as well as their clinical integration, limitations, and prospects.<\/jats:p>","DOI":"10.1002\/jgh3.70377","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:24:52Z","timestamp":1773030292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progress in Gastroparesis Management: From Pharmacotherapy to Interventional Treatments"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-8042","authenticated-orcid":false,"given":"Ganesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Medicine Chandka Medical College  Larkana Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yash","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ume","family":"Rooman","sequence":"additional","affiliation":[{"name":"Department of Medicine People University of Medical and Health Sciences for Women  Shaheed Benazirabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Trinity Health Oakland\/Wayne State University  Pontiac Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9170-4615","authenticated-orcid":false,"given":"Shireen","family":"Asifa","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qais M.","family":"Salah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-9039","authenticated-orcid":false,"given":"Dushyant Singh","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Motility The University of Kansas School of Medicine  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-2569","authenticated-orcid":false,"given":"Arkadeep","family":"Dhali","sequence":"additional","affiliation":[{"name":"Academic Unit of Gastroenterology Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"},{"name":"Faculty of Life Science &amp; Medicine King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia","family":"Arsene","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Trinity Health Oakland\/Wayne State University  Pontiac Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meer","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2014.11.001"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0038-z"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16474"},{"key":"e_1_2_16_5_1","unstructured":"C.Rayner Gastroenterological Society of Australia Position Statement on the Assessment and Management of Idiopathic Gastroparesis 2025 www.gesa.org.au."},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318712"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1645594"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2023.2196404"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06129-0"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2014.11.011"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.25"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.12.033"},{"key":"e_1_2_16_13_1","volume-title":"Gastroparesis","author":"Reddivari A. 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