{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:10:15Z","timestamp":1777295415115,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["43014454"],"award-info":[{"award-number":["43014454"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder influenced by various dietary factors. This study aimed to evaluate the association between dietary intake of vitamin B6 and the risk of GERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2013control study included 150 women with GERD and 300 controls in Tehran, Iran. Dietary intake of vitamin B6 was assessed using a validated food frequency questionnaire (FFQ) and analyzed with Nutritionist IV software. Logistic regression models were applied to determine the association between GERD risk and dietary intake of vitamin B6, adjusting for age, education, marital status, occupation, physical activity, BMI, and calorie intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with participants in the lowest tertile of vitamin B6 intake, those in the highest tertile had significantly higher odds of GERD in age\u2010adjusted models (OR\u2009=\u20091.98, 95% CI: 1.12\u20133.51) and this association remained significant after further adjustment for sociodemographic factors, physical activity, BMI (OR\u2009=\u20092.05, 95% CI: 1.10\u20133.83), and total energy intake (OR\u2009=\u20092.02, 95% CI: 1.06\u20133.81). No significant association was observed for the middle tertile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings of this case\u2013control study indicate a positive association between higher dietary vitamin B6 intake and the risk of GERD. Further prospective research would be helpful to confirm these observations and to shed light on possible biological mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70398","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:59:02Z","timestamp":1776225542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Vitamin\n                    <scp>B6<\/scp>\n                    Intake and Gastroesophageal Reflux Disease: A Case\u2013Control Study"],"prefix":"10.1002","volume":"10","author":[{"given":"Amirhesam","family":"Mehrara","sequence":"first","affiliation":[{"name":"School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Moradi","sequence":"additional","affiliation":[{"name":"Departmant of Medicine Qazvin University of Medical Sciences  Qazvin Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh","family":"Dorosti","sequence":"additional","affiliation":[{"name":"Student Research Committee, Department of Nutrition, Faculty of Medicine Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Dehghanian","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Science, School of Nutrition &amp; Food Technology, National Nutrition &amp; Food Research Institute  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh Sadat","family":"MirShafaie","sequence":"additional","affiliation":[{"name":"Department of Sport Physiology, Tonekabon Branch Islamic Azad University  Tonekabon Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Esfahanian","sequence":"additional","affiliation":[{"name":"School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bita","family":"Moradi","sequence":"additional","affiliation":[{"name":"Nursing and Midwifery Department Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Nouri","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Science  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Khoshdooz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Guilan University of Medical Science  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parsa","family":"Bahmani","sequence":"additional","affiliation":[{"name":"Cancer Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-4963","authenticated-orcid":false,"given":"Saeid","family":"Doaei","sequence":"additional","affiliation":[{"name":"Cancer Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Gholamalizadeh","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.09.162"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62795-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01417-6"},{"key":"e_1_2_11_6_1","unstructured":"K.Tuerxun M.Balati M.Aimaiti et\u00a0al. \u201cEpidemiological Investigation Extraesophageal Symptoms and Risk Factors of Gastroesophageal Reflux Disease in Kashgar Xinjiang China \u201d13 no.12(2021):14186."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15902"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071714-034330"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511000407"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","unstructured":"L.Sharp A. E.Carsin M. M.Cantwell et\u00a0al. \u201cIntakes of Dietary Folate and Other B Vitamins Are Associated With Risks of Esophageal Adenocarcinoma Barrett's Esophagus and Reflux Esophagitis \u201d143 no.12(2013):1966\u20131973.","DOI":"10.3945\/jn.113.174664"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18114"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020376"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.567650"},{"issue":"8","key":"e_1_2_11_15_1","first-page":"1073","article-title":"The Iranian Version of International Physical Activity Questionnaire (IPAQ) in Iran: Content and Construct Validity, Factor Structure, Internal Consistency and Stability","volume":"18","author":"Moghaddam M. 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