{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:25:28Z","timestamp":1788279928700,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gastroesophageal reflux disease (GERD) is a chronic relapsing disorder often inadequately controlled with proton pump inhibitors (PPIs), particularly in patients with nocturnal acid breakthrough (NAB) or non\u2010erosive reflux disease (NERD). Tegoprazan, a potassium\u2010competitive acid blocker (PCAB), offers rapid, potent, and CYP2C19\u2010independent acid suppression. This systematic review and meta\u2010analysis evaluated randomized controlled trials comparing Tegoprazan with PPIs in adults with GERD and related disorders. Databases searched included PubMed, Cochrane, Wiley, and\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    (2015\u20132026). Eighteen studies met inclusion criteria. In erosive esophagitis, Tegoprazan 50\u2009mg once daily achieved mucosal healing rates of 91.1%\u201399.1%, non\u2010inferior to PPIs (93.5%\u201398.9%; pooled RR\u2009=\u20091.01, 95% CI 0.98\u20131.05). Pharmacodynamic and clinical studies demonstrated faster acid suppression and improved nocturnal pH control versus PPIs, achieving pH \u2265\u20094 within 30\u201360\u2009min and maintaining levels throughout the 12\u2010h period. In nocturnal symptom analyses, Tegoprazan achieved earlier relief (1.5 vs. 3\u2009days to first heartburn\u2010free night) and higher proportions of heartburn\u2010free nights (57.8% vs. 43.1%), with significantly greater complete (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.038) and partial (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034) nighttime symptom resolution than Esomeprazole. In NERD, symptom resolution ranged from 42.5% to 48.9% versus 24.2% with placebo. In open\u2010label functional dyspepsia cohorts, improvements ranged from 74.6% to 86.7% in open\u2010label cohorts. Seven trials (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092492) showed higher\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    eradication with Tegoprazan\u2010based therapy (RR\u2009=\u20091.05, 95% CI 1.01\u20131.09;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090%). Adverse events were mild and comparable to PPIs. Tegoprazan provides rapid, sustained acid suppression, effective nocturnal symptom control, and a modest but statistically significant improvement in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    eradication, representing a potential alternative to PPIs for patients with persistent or CYP2C19\u2010related variable response.\n                  <\/jats:p>","DOI":"10.1002\/jgh3.70406","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:42:13Z","timestamp":1776476533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tegoprazan in Gastroesophageal Reflux Disease and Related Acid\u2010Mediated Conditions: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0812-2810","authenticated-orcid":false,"given":"Sanjay","family":"Bandyopadhyay","sequence":"first","affiliation":[{"name":"ILS Hospital, Dumdum  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Goenka","sequence":"additional","affiliation":[{"name":"Institute of Gastrosciences, Apollo Gleneagles Hospitals  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debapratim","family":"Routh","sequence":"additional","affiliation":[{"name":"Charnock Hospital  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. N.","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Aster Medcity  Kochi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parimal","family":"Lawate","sequence":"additional","affiliation":[{"name":"Deenanath Mangeshkar Hospital  Pune 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