{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:08:31Z","timestamp":1779966511191,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with cirrhosis have an increased risk of developing complications secondary to thrombocytopenia. This study aims to investigate post\u2010ERCP outcomes in patients with liver cirrhosis and concomitant low platelet count who undergo endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis in a large, matched cohort with cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted using data from the TriNetX research network. Patients aged 18\u2009years or older with cirrhosis undergoing ERCP for choledocholithiasis were included. Cohorts were categorized by platelet count into mild or moderate thrombocytopenia groups, with 5097 patients in each cohort after propensity score matching, yielding a total of 10\u2009194 patients. Univariate regression analysis was used to assess the primary outcome, namely, all\u2010cause mortality. Secondary outcomes included post\u2010ERCP bleeding, post\u2010ERCP pancreatitis, need for blood transfusion, and other adverse events such as sepsis and acute kidney injury (AKI). Odds ratios (ORs) and 95% confidence intervals (CIs) were then calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All\u2010cause mortality [OR 1.54 (95% CI): (1.32\u20131.80)] and need for blood transfusion (OR 1.37; 95% CI 1.17\u20131.61) were higher among patients with moderate thrombocytopenia. However, adverse events, including post\u2010ERCP bleeding (OR 0.96; 95% CI 0.72\u20131.3), post\u2010ERCP pancreatitis (OR 0.81; 95% CI 0.69\u20131.02), sepsis (OR 1.04; 95% CI 0.93\u20131.16), and AKI (OR 1.11; 95% CI 1.00\u20131.23), were statistically not significant between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The cirrhotic population with moderate thrombocytopenia undergoing ERCP for choledocholithiasis experiences significantly worse outcomes compared to those with mild thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70418","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:15:51Z","timestamp":1779336951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post\u2010\n                    <scp>ERCP<\/scp>\n                    Outcomes in Cirrhotic Patients With Thrombocytopenia: A Propensity\u2010Matched Retrospective Comparative Analysis on\n                    <scp>TriNetX<\/scp>\n                    Health Research Database"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-1994","authenticated-orcid":false,"given":"Umar","family":"Hayat","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Geisinger Wyoming Valley Medical Center  Wilkes Barre Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine SUNY Upstate University Hospital  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-9197","authenticated-orcid":false,"given":"Hassam","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology East Carolina University  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9345-6071","authenticated-orcid":false,"given":"Karan J.","family":"Yagnik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rutgers\/Monmouth Medical Center  Long Branch New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Geisinger Medical Center  Danville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Inova Fairfax Hospital, University of Virginia School of Medicine  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-2823","authenticated-orcid":false,"given":"Sumant","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshit S.","family":"Khara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Geisinger Medical Center  Danville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Confer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Geisinger Medical Center  Danville Pennsylvania 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