{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:06:07Z","timestamp":1785139567336,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Functional dyspepsia (FD) often overlaps with GERD\u2010, IBS\u2010, and FC\u2010like symptoms, complicating treatment. This study evaluated overlap patterns and their association with cinitapride response in Chinese FD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter prospective observational study, 1297 Chinese FD patients meeting Rome IV criteria received cinitapride 1\u2009mg three times daily for 4\u2009weeks. Overlapping symptoms were classified as GERD\u2010like, IBS\u2010like, or FC\u2010like. Patients were grouped by overlap complexity: no overlap, one overlapping symptom domain, or two overlapping symptom domains. Symptom improvement was defined as a\u2009\u2265\u200950% reduction in symptom score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 58.1% of patients had overlapping symptoms: 38.2% had one overlapping domain and 19.9% had two. GERD\u2010like symptoms were the most common isolated overlap and were present in all two\u2010domain overlap cases. IBS\u2010like symptoms, mainly IBS\u2010C\u2010like, predominated among patients with two overlapping domains. Symptom burden increased with overlap complexity, peaking in the GERD\u2010like + IBS\u2010like group. FD\u2010related improvement after cinitapride declined progressively from patients without overlap to those with one and two overlapping domains. After adjustment for demographic and clinical factors, greater overlap complexity remained associated with reduced odds of FD\u2010related response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Symptom overlap is common in Chinese FD patients, especially GERD\u2010like overlap. GERD+IBS overlap was linked to the greatest symptom burden and poorest observed response to cinitapride, suggesting that symptom\u2010defined overlap phenotypes may support more individualized management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      Clinical efficacy and safety of prokinetic agents as maintenance therapy for functional dyspepsia (FD): a real\u2010world study: ChiCTR2100042166.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\/hvshowproject.html?id=84789&amp;v=1.0\">https:\/\/www.chictr.org.cn\/hvshowproject.html?id=84789&amp;v=1.0<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70438","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:53:06Z","timestamp":1784105586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptom Overlap Stratifies Prokinetic Response in Functional Dyspepsia: A Real\u2010World Multicenter Study of 1297 Chinese Patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-1788","authenticated-orcid":false,"given":"Dan","family":"Zhou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Bai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-2126","authenticated-orcid":false,"given":"Xiaohua","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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