{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:19:11Z","timestamp":1787815151380,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study evaluated the diagnostic performance of Golgi protein 73 (GP73), laminin\u2010\u03b32 monomer (LG2m), and the GLAS score in detecting advanced fibrosis in patients with metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included patients with MASLD who underwent liver biopsy. The performance of serum levels of GP73 and LG2m and the GLAS score to diagnose advanced fibrosis was evaluated using area under receiver operating characteristic curves (AUROC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The data for 209 patients with MASLD were analyzed [median age 52 (42\u201358) years, 53.1% men, 71.3% had steatohepatitis, 18.1% had advanced fibrosis]. The serum levels of GP73 and LG2m and the GLAS score were significantly higher in patients with advanced fibrosis compared to patients without advanced fibrosis [GP73: 83\u2009\u00b1\u200950\u2009ng\/mL vs. 61\u2009\u00b1\u200935\u2009ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013; LG2m: 31 (14\u201348) pg\/mL vs. 17 (12\u201323) pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; GLAS score: 0.89 (0.49\u20130.97) vs. 0.47 (0.15\u20130.78),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001]. The AUROC of serum levels of GP73 and LG2m and GLAS for diagnosing advanced fibrosis was 0.63 (0.52\u20130.74), 0.73 (0.62\u20130.83), and 0.72 (0.61\u20130.82), respectively. Using the optimal cut\u2010off of 27\u2009pg\/mL, the sensitivity, specificity, positive predictive value, and negative predictive value of LG2m for diagnosing advanced fibrosis were 60.5%, 86.0%, 48.9%, and 90.7%, respectively. Using the optimal cut\u2010off of 0.75, the corresponding values for the GLAS score were 65.8%, 73.7%, 35.7%, and 90.6%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum LG2m level and the GLAS score have fair accuracy for the diagnosis of advanced fibrosis in patients with MASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70455","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:20:12Z","timestamp":1785730812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Golgi Protein 73 and Laminin\u2010\u03b32 Monomer\u2010Based Score for the Diagnosis of Advanced Liver Fibrosis in Patients With Metabolic Dysfunction\u2010Associated Steatotic Liver Disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Xin\u2010Tong","family":"Ng","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Gastroenterology and Hepatology Unit, Department of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ying","family":"Teh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Gastroenterology and Hepatology Unit, Department of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7518-4217","authenticated-orcid":false,"given":"Pavai","family":"Sthaneshwar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Clinical Diagnostic Laboratory, Department of Pathology University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9825-1753","authenticated-orcid":false,"given":"Izzatul Aliaa","family":"Badaruddin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical Diagnostic Laboratory, Department of Pathology Universiti Kebangsaan Malaysia  Bangi Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-0022","authenticated-orcid":false,"given":"Pavitratha","family":"Puspanathan","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Pulau Pinang  Pulau Pinang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nik Raihan","family":"Nik Mustapha","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Sultanah Bahiyah  Alor Setar Kedah Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-0590","authenticated-orcid":false,"given":"Sanjiv","family":"Mahadeva","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Gastroenterology and Hepatology Unit, Department of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-5837","authenticated-orcid":false,"given":"Wah\u2010Kheong","family":"Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Gastroenterology and Hepatology Unit, Department of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0431"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i11.1450"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27368"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443344"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80075-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.084"},{"issue":"6","key":"e_1_2_11_8_1","first-page":"560","article-title":"Nonalcoholic Fatty Liver Disease: Assessment of Variability in Pathologic Interpretations","volume":"11","author":"Younossi Z. 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