{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:01:13Z","timestamp":1790319673557,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) remains a major cause of cancer mortality, with up to 26% of adenomas missed on conventional colonoscopy. Artificial intelligence (AI)\u2013based computer\u2010aided detection (CADe) systems may reduce these miss rates. We aimed to validate the iIDEAS\u2010C CADe module in a prospective cohort, with co\u2010primary endpoints of adenomas per colonoscopy (APC) and lesion\u2010level miss rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>In this prospective, nonrandomized, single\u2010center study (NCT05784935), consecutive adults (18\u201375\u2009years) undergoing screening, surveillance, or diagnostic colonoscopy were enrolled between February and May 2023. Each colon segment was inspected twice: an initial blinded withdrawal without CADe, followed by a second inspection with iIDEAS\u2010C. Missed lesions were those identified by CADe during the second inspection and confirmed endoscopically. Secondary outcomes included PDR, ADR, PPC, lesion characteristics, and procedural times.<\/jats:p>\n                    <jats:p>\n                      Two hundred patients (mean age 44.1\u2009\u00b1\u200912.7\u2009years; 64% male) were included. Eighty\u2010two polyps were detected across 42 patients (PDR\u2009=\u200921%). Endoscopists detected 61\/82 polyps (74.4%), yielding a per\u2010polyp miss rate of 25.6%. The iIDEAS\u2010C module detected all 82 lesions, achieving 0% per\u2010polyp and per\u2010adenoma miss rate. Missed lesions were mostly diminutive and proximal. PPC increased from 0.305 to 0.410 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), PDR from 17.5% to 21.0% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), and APC from 0.115 to 0.140 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029). No adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The iIDEAS\u2010C module demonstrated a 0% lesion\u2010level miss rate and significantly improved key detection metrics, especially for small proximal lesions. Larger multicenter studies are warranted to confirm these findings and assess long\u2010term outcomes.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT05784935.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: NCT05784935.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70470","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:50:08Z","timestamp":1789703408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010Time\n                    <scp>AI<\/scp>\n                    \u2010Assisted Detection of Colonic Lesions Using the\n                    <scp>iIDEAS<\/scp>\n                    Intelligent\u2010C Module: A Prospective Single\u2010Center Validation Study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-9986","authenticated-orcid":false,"given":"Hardik","family":"Rughwani","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology Hospitals (AIG Hospitals)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1343-9939","authenticated-orcid":false,"given":"Rajat","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Texas Health  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-4464","authenticated-orcid":false,"given":"Sana Fathima","family":"Memon","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology Hospitals (AIG Hospitals)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Kwong","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine The Chinese University of Hong Kong  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biji","family":"Sreedhar","sequence":"additional","affiliation":[{"name":"Director of Clinical Affairs, iEMIS (HK) Limited  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwun Ping","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Artificial Intelligence iEMIS (HK) Limited  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-3638","authenticated-orcid":false,"given":"Rajendra","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology Hospitals (AIG Hospitals)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-0164","authenticated-orcid":false,"given":"Nitin","family":"Jagtap","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology Hospitals (AIG Hospitals)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7023-3589","authenticated-orcid":false,"given":"Syed Jameel","family":"Hussain","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology Hospitals (AIG Hospitals)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Sanny","sequence":"additional","affiliation":[{"name":"Asian Institute of Gastroenterology Hospitals (AIG Hospitals)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3203-7708","authenticated-orcid":false,"given":"Rakesh","family":"Kalapala","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology Hospitals (AIG Hospitals)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-0496","authenticated-orcid":false,"given":"D. Nageshwar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology Hospitals (AIG Hospitals)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292701"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.06.039"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.260"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1309086"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.11.014"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.06.059"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1201-7165"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","unstructured":"B.Singh H.Li A.Sharma andL. S.Davis \u201cR\u2010fcn\u20103000 at 30\u2009fps: Decoupling detection and classification \u201dinProceedings of the IEEE Conference on Computer Vision and Pattern Recognition2018.","DOI":"10.1109\/CVPR.2018.00119"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","unstructured":"K.He X.Zhang S.Ren andJ.Sun \u201cDeep Residual Learning for Image Recognition \u201dinProceedings of the IEEE Conference on Computer Vision and Pattern Recognition2016.","DOI":"10.1109\/CVPR.2016.90"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/M22-3678"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.062"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731977"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301969"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317500"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314547"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.01.002"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-082656"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2543-0370"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-00981"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.70470","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:54:52Z","timestamp":1790319292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jgh3.70470"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70470","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70470"}}