{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:01:23Z","timestamp":1790319683715,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The uric acid\u2010to\u2010albumin ratio (UAR) has shown prognostic value in several inflammatory conditions, but its role in acute pancreatitis (AP) remains unclear. This study evaluated the prognostic value of UAR for disease severity in patients with AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center, retrospective study, 147 patients hospitalized with acute pancreatitis between February 2025 and June 2026 were included. UAR, systemic immune\u2010inflammation index (SII), and platelet\u2010to\u2010lymphocyte ratio (PLR) were calculated. Disease severity was classified using the revised Atlanta classification and the BISAP score. Diagnostic performance was assessed by receiver operating characteristic (ROC) analysis with pairwise area under the curve (AUC) comparisons (DeLong method).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010eight patients (25.9%) had moderate\u2010to\u2010severe AP. UAR was higher in the moderate\u2010to\u2010severe group than in the mild group (1.65\u2009\u00b1\u20090.47 vs. 1.27\u2009\u00b1\u20090.34;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and increased across BISAP score categories (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). UAR had an AUC of 0.741 (95% CI: 0.662\u20130.810), compared with 0.706 for SII and 0.646 for PLR; however, pairwise differences were not statistically significant. At a cut\u2010off of &gt;\u20091.54 (Youden index), UAR had a specificity of 82.57% and a negative predictive value of 84.90%. Combining UAR with age increased the AUC to 0.801 and the negative predictive value to 88.57%. Bootstrap validation yielded an optimism\u2010corrected AUC of 0.794. UAR was associated with moderate\u2010to\u2010severe AP in univariable analysis (OR: 10.517; 95% CI: 3.770\u201329.336;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not after multivariable adjustment (adjusted OR: 3.462; 95% CI: 0.870\u201313.773;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.078).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UAR is a simple, inexpensive biomarker with potential utility in acute pancreatitis severity assessment. Although not independently predictive, it may provide complementary information alongside clinical and laboratory findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70471","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:26:37Z","timestamp":1790047597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Performance of the Uric Acid\u2010To\u2010Albumin Ratio in Predicting Severity of Acute Pancreatitis"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2361-5011","authenticated-orcid":false,"given":"H\u00fcsn\u00fc Serdar","family":"K\u0131z\u0131ltun\u00e7","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Amasya University Faculty of Medicine  Amasya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9878-2554","authenticated-orcid":false,"given":"\u015eirin","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Amasya University Faculty of Medicine  Amasya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2654-8640","authenticated-orcid":false,"given":"Mehmet Batuhan","family":"Duman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gebze Fatih State Hospital  Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010026\u201005976\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.09.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1427"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130412"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2026.1764029"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010025\u201012134\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.15441\/ceem.20.024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000046123"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.9280"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010024\u201004425\u20102"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-019-0247-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010025\u201004240\u2010z"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AVSG.2024.05.032"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306178"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/jdr\/9721061"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.106664"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.21470\/1678\u20109741\u20102024\u20100348"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.14156"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845\u2010026\u201004366\u20103"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.14744\/tjtes.2025.48804"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_1959_24"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.sjg_462_25"}],"container-title":["JGH 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