{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:53:38Z","timestamp":1791258818770,"version":"4.1.0"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Ulcerative colitis (UC) is a diffuse, nonspecific inflammation of the colon of unknown cause. Basic and clinical studies suggest that UC may be ameliorated by dietary fiber intake. Fermented brown rice by\n Aspergillus oryzae<\/jats:italic>\n (FBRA) is produced by fermenting brown rice and bran with\n A. oryzae<\/jats:italic>\n . We aimed to evaluate the efficacy of FBRA in patients with UC by a double\u2010blind, randomized crossover trial.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Patients were divided into two groups: Group A (administered FBRA for 14\u2009weeks, followed by a washout period, and then administered nonfunctional foods (NF) for 14\u2009weeks) and Group B (NF and then FBRA). The primary endpoint is the presence or absence of improvement in clinical activity index (CAI) scores before and after the intervention. The secondary endpoints are the pre\u2010 and postintervention changes in blood data indicating inflammation (e.g., high\u2010sensitivity C\u2010reactive protein (CRP)) and nutritional status (e.g., serum proteins), and the adverse events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Fifty\u2010six patients consented to participate: 19 in Group A and 21 in Group B completed the trial. Improvement in the CAI scores was not observed with FBRA. In the ITT analysis of the blood data, however, high\u2010sensitivity CRP, erythrocyte sedimentation rate hourly, white blood cell count, serum protein level, and serum albumin level all tended to be improved from the preintervention level (improvement ratio 1.70; 95% CI 0.97\u20132.98). No serious adverse event was observed.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n There is an expectation that FBRA may be effective in improving inflammation in patients with UC. Therefore, a large\u2010scale validation study should be conducted in the future.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jgh3.70476","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:31:42Z","timestamp":1791257502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Fermented Brown Rice by\n Aspergillus oryzae<\/i>\n (\n FBRA<\/scp>\n ) in Ulcerative Colitis: A Double\u2010Blind Randomized Trial"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-698X","authenticated-orcid":false,"given":"Hideki","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Molecular\u2010Targeted Preventive Medicine Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Molecular Bacteriology, Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Molecular Bacteriology, Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Toho University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-7655","authenticated-orcid":false,"given":"Michihiro","family":"Mutoh","sequence":"additional","affiliation":[{"name":"Molecular\u2010Targeted Preventive Medicine Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Sapporo Cancer Seminar Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"6","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cgh.2020.05.026","article-title":"Low\u2010Fat, High\u2010Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis","volume":"19","author":"Fritsch J.","year":"2021","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"3","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2152\/jmi.58.235","article-title":"Effects of Fermented Brown Rice on the Intestinal Environments in Healthy Adults","volume":"58","author":"Nemoto H.","year":"2011","journal-title":"Journal of Medical Investigation"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0968-0896(01)00386-8","article-title":"Syntheses of Ferulic Acid Derivatives and Their Suppressive Effects on Cyclooxygenase\u20102 Promoter Activity","volume":"10","author":"Hosoda A.","year":"2002","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s10620-007-0063-3","article-title":"Inhibitory Effects of Fermented Brown Rice on Induction of Acute Colitis by Dextran Sulfate Sodium in Rats","volume":"53","author":"Kataoka K.","year":"2008","journal-title":"Digestive Diseases and Sciences"},{"key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1056\/NEJM199406303302601","article-title":"Cyclosporine in Severe Ulcerative Colitis Refractory to Steroid Therapy","volume":"330","author":"Lichtiger S.","year":"1994","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"e_1_2_13_7_1","first-page":"643","article-title":"Germinated Barley Foodstuff Prolongs Remission in Patients With Ulcerative Colitis","volume":"13","author":"Hanai H.","year":"2004","journal-title":"International Journal of Molecular Medicine"}],"container-title":["JGH Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgh3.70476","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgh3.70476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:31:45Z","timestamp":1791257505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgh3.70476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jgh3.70476"],"URL":"https:\/\/doi.org\/10.1002\/jgh3.70476","archive":["Portico"],"relation":{},"ISSN":["2397-9070","2397-9070"],"issn-type":[{"value":"2397-9070","type":"print"},{"value":"2397-9070","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70476"}}