{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:48:23Z","timestamp":1791776903681,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JGH Open"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Daikenchuto (DKT), a Kampo medicine, is widely used in surgical practice because of its pro\u2010motility effects on the gastrointestinal tract. Although its anti\u2010inflammatory effects in the gastrointestinal tract have been well documented, its role in hepatic ischemia\u2013reperfusion injury (IRI) remains unclear. This study investigated the protective effects of DKT and its individual components against hepatic IRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male C57BL\/6 mice were fed a diet containing 3.6% DKT or its individual herbal components for 1\u2009week before 60\u2009min of partial hepatic ischemia. Liver injury was evaluated based on serum liver enzyme levels, histology, and TUNEL staining. Portal venous adrenomedullin (ADM) levels and hepatic heme oxygenase\u20101 (HO\u20101) expression were also assessed. In\u00a0vitro, peritoneal macrophages were stimulated with High Mobility Group Box\u00a01 (HMGB1) to examine the effects of DKT and 6\u2010shogaol (6SG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DKT significantly reduced serum alanine aminotransferase levels, necrotic area, and hepatocyte apoptosis compared to the control. Although single\u2010herb doses equivalent to those in the DKT formula did not confer protection, a threefold dose of processed ginger reproduced the hepatoprotective effects of DKT. DKT did not increase portal ADM levels. In contrast, both DKT and 6SG significantly upregulated HO\u20101 expression in\u00a0vivo and suppressed the production of inflammatory cytokines in HMGB1\u2010stimulated macrophages in\u00a0vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DKT attenuates liver IRI via HO\u20101 induction and suppression of macrophage\u2010mediated inflammation, rather than via ADM elevation. These protective effects may be mediated, at least in part, by processed ginger.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgh3.70478","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:40:13Z","timestamp":1791776413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Daikenchuto and Processed Ginger Alleviate Liver Ischemia\u2013Reperfusion Injury by Enhancing Anti\u2010Inflammatory Effects and\n                    <scp>HO<\/scp>\n                    \u20101 Production"],"prefix":"10.1002","volume":"10","author":[{"given":"Kenichi","family":"Saga","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"},{"name":"Department of Gastroenterological Surgery and Oncology Medical Research Institute KITANO HOSPITAL  Osaka 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