{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T15:01:47Z","timestamp":1715958107779},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T00:00:00Z","timestamp":1284595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical studies have shown that gene therapy is a promising approach for treating such genetic diseases as the eye disease, Leber's congenital amaurosis. Development of gene therapy approaches for treating chronic inflammatory diseases is, however, more challenging because it requires the production of anti\u2010inflammatory molecules at the diseased tissues only when they are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed such a system by modifying the human interleukin (IL)\u20106 gene promoter to direct transgene expression and delivered the system into cultured cells as well as mouse lungs using a helper\u2010dependent adenoviral vector.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We have demonstrated both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> that the reporter LacZ or human IL\u201010 gene can be induced by inflammatory stimuli.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results obtained indicate that the inflammation inducible gene expression system based on the modified human IL\u20106 gene promoter has the potential to be used for developing gene therapy for treating inflammatory diseases. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.1501","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T04:28:16Z","timestamp":1284697696000},"page":"832-839","source":"Crossref","is-referenced-by-count":3,"title":["Development of an inflammation\u2010inducible gene expression system using helper\u2010dependent adenoviral vectors"],"prefix":"10.1002","volume":"12","author":[{"given":"Tianyao","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongqi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Keith Tanswell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.879"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23598"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652308783688482"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302182"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1053"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1105674"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00210-9"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2005.16.1"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302968"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.797"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.57"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240450404"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302712"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-237-3_3"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2001.0412"}],"container-title":["The Journal of Gene Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgm.1501","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgm.1501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:59:23Z","timestamp":1700571563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgm.1501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,16]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1002\/jgm.1501"],"URL":"https:\/\/doi.org\/10.1002\/jgm.1501","archive":["Portico"],"relation":{},"ISSN":["1099-498X","1521-2254"],"issn-type":[{"value":"1099-498X","type":"print"},{"value":"1521-2254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,16]]}}}