{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:30:25Z","timestamp":1759588225167},"reference-count":42,"publisher":"Wiley","issue":"1-3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Gene Med"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1002\/jgm.2872","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T13:05:05Z","timestamp":1452863105000},"page":"16-26","source":"Crossref","is-referenced-by-count":8,"title":["A single adenovirus-mediated relaxin delivery attenuates established liver fibrosis in rats"],"prefix":"10.1002","volume":"18","author":[{"given":"Ja Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine; Yonsei University College of Medicine; Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine; Yonsei University College of Medicine; Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Han","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Samsung Medical Centre; Sungkyunkwan University School of Medicine; Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae-Ok","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, College of Engineering; Hanyang University; Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Young","family":"Chang","sequence":"additional","affiliation":[{"name":"Medical Research Centre, Gangnam Severance Hospital; Yonsei University College of Medicine; Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Research Centre, Gangnam Severance Hospital; Yonsei University College of Medicine; Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine; Yonsei University College of Medicine; Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"10.1002\/jgm.2872-BIB0001|jgm2872-cit-0002","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1002\/jgm.2872-BIB0002|jgm2872-cit-0003","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-2001-17556","article-title":"Matrix as a modulator of hepatic fibrogenesis","volume":"21","author":"Schuppan","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1002\/jgm.2872-BIB0003|jgm2872-cit-0004","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","article-title":"Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies","volume":"46","author":"Hemmann","year":"2007","journal-title":"J Hepatol"},{"key":"10.1002\/jgm.2872-BIB0004|jgm2872-cit-0005","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.273.5278.1078","article-title":"A crosslinked cofactor in lysyl oxidase: redox function for amino acid side chains","volume":"273","author":"Wang","year":"1996","journal-title":"Science"},{"key":"10.1002\/jgm.2872-BIB0005|jgm2872-cit-0006","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0945-053X(98)90012-9","article-title":"Lysyl oxidase: properties, regulation and multiple functions in biology","volume":"16","author":"Smith-Mungo","year":"1998","journal-title":"Matrix Biol"},{"key":"10.1002\/jgm.2872-BIB0006|jgm2872-cit-0007","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jhep.2011.09.024","article-title":"Clinical evidence for the regression of liver fibrosis","volume":"56","author":"Ellis","year":"2012","journal-title":"J Hepatol"},{"key":"10.1002\/jgm.2872-BIB0007|jgm2872-cit-0008","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0140-6736(12)61425-1","article-title":"Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study","volume":"381","author":"Marcellin","year":"2013","journal-title":"Lancet"},{"key":"10.1002\/jgm.2872-BIB0008|jgm2872-cit-0009","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1210\/er.2003-0013","article-title":"Relaxin's physiological roles and other diverse actions","volume":"25","author":"Sherwood","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1002\/jgm.2872-BIB0009|jgm2872-cit-0010","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1210\/endo-123-5-2486","article-title":"Monoclonal antibodies specific for rat relaxin. III. Passive immunization with monoclonal antibodies throughout the second half of pregnancy reduces cervical growth and extensibility in intact rats","volume":"123","author":"Hwang","year":"1988","journal-title":"Endocrinology"},{"key":"10.1002\/jgm.2872-BIB0010|jgm2872-cit-0011","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1210\/endo.139.11.6327","article-title":"Monoclonal antibodies specific for rat relaxin. X. Endogenous relaxin induces changes in the histological characteristics of the rat vagina during the second half of pregnancy","volume":"139","author":"Zhao","year":"1998","journal-title":"Endocrinology"},{"key":"10.1002\/jgm.2872-BIB0011|jgm2872-cit-0012","doi-asserted-by":"crossref","first-page":"10681","DOI":"10.1016\/S0021-9258(18)87000-4","article-title":"Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts","volume":"265","author":"Unemori","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1002\/jgm.2872-BIB0012|jgm2872-cit-0013","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1172\/JCI119099","article-title":"Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo","volume":"98","author":"Unemori","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1002\/jgm.2872-BIB0013|jgm2872-cit-0014","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1523-1755.2005.00384.x","article-title":"The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway","volume":"68","author":"Heeg","year":"2005","journal-title":"Kidney Int"},{"key":"10.1002\/jgm.2872-BIB0014|jgm2872-cit-0015","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1210\/en.2008-0250","article-title":"Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy","volume":"149","author":"Samuel","year":"2008","journal-title":"Endocrinology"},{"key":"10.1002\/jgm.2872-BIB0015|jgm2872-cit-0016","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1172\/JCI112041","article-title":"Influences of gamma interferon on synovial fibroblast-like cells. Ia induction and inhibition of collagen synthesis","volume":"76","author":"Amento","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1002\/jgm.2872-BIB0016|jgm2872-cit-0017","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/liv.12247","article-title":"Relaxin decreases the severity of established hepatic fibrosis in mice","volume":"34","author":"Bennett","year":"2014","journal-title":"Liver Int"},{"key":"10.1002\/jgm.2872-BIB0017|jgm2872-cit-0018","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/hep.26627","article-title":"Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo","volume":"59","author":"Fallowfield","year":"2014","journal-title":"Hepatology"},{"key":"10.1002\/jgm.2872-BIB0018|jgm2872-cit-0019","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1089\/104303401750270977","article-title":"Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved - deletion of the viral E1b-19-kD gene increases the viral oncolytic effect","volume":"12","author":"Harrison","year":"2001","journal-title":"Hum Gene Ther"},{"key":"10.1002\/jgm.2872-BIB0019|jgm2872-cit-0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1089\/104303403321467199","article-title":"Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points","volume":"14","author":"Sauthoff","year":"2003","journal-title":"Hum Gene Ther"},{"key":"10.1002\/jgm.2872-BIB0020|jgm2872-cit-0021","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/jnci\/djj397","article-title":"Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy","volume":"98","author":"Kim","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/jgm.2872-BIB0021|jgm2872-cit-0022","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2133.2011.10439.x","article-title":"Adenovirus-relaxin gene therapy for keloids: implication for reversing pathological fibrosis","volume":"165","author":"Lee","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1002\/jgm.2872-BIB0022|jgm2872-cit-0023","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/jor.22535","article-title":"Down-regulation of collagen synthesis and matrix metalloproteinase expression in myofibroblasts from Dupuytren nodule using adenovirus-mediated relaxin gene therapy","volume":"32","author":"Kang","year":"2014","journal-title":"J Orthop Res"},{"key":"10.1002\/jgm.2872-BIB0023|jgm2872-cit-0024","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/sj.cgt.7700494","article-title":"Evaluation of E1B gene-attenuated replicating adenoviruses for cancer gene therapy","volume":"9","author":"Kim","year":"2002","journal-title":"Cancer Gene Ther"},{"key":"10.1002\/jgm.2872-BIB0024|jgm2872-cit-0025","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1073\/pnas.96.2.355","article-title":"Adenovirus-mediated regulable target gene expression in vivo","volume":"96","author":"Burcin","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/jgm.2872-BIB0025|jgm2872-cit-0026","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF01535207","article-title":"Histochemical staining of clonal mammalian cell lines expressing E. coli beta galactosidase indicates heterogeneous expression of the bacterial gene","volume":"13","author":"MacGregor","year":"1987","journal-title":"Somat Cell Mol Genet"},{"key":"10.1002\/jgm.2872-BIB0026|jgm2872-cit-0027","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1309\/D7AU-EYW7-4B6C-K08Y","article-title":"An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C","volume":"114","author":"O'Brien","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"10.1002\/jgm.2872-BIB0027|jgm2872-cit-0028","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0168-8278(03)00411-2","article-title":"Apoptosis of hepatic stellate cells in carbon tetrachloride induced acute liver injury of the rat: analysis of isolated hepatic stellate cells","volume":"39","author":"Lee","year":"2003","journal-title":"J Hepatol"},{"key":"10.1002\/jgm.2872-BIB0028|jgm2872-cit-0029","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hep.510270313","article-title":"Fibrogenic effect of oxidative stress on rat hepatic stellate cells","volume":"27","author":"Svegliati Baroni","year":"1998","journal-title":"Hepatology"},{"key":"10.1002\/jgm.2872-BIB0029|jgm2872-cit-0030","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1053\/jhep.2001.22520","article-title":"Rat hepatic stellate cells contribute to the acute-phase response with increased expression of alpha1(I) and alpha1(IV) collagens, tissue inhibitor of metalloproteinase-1, and matrix-metalloproteinase-2 messenger RNAs","volume":"33","author":"Nieto","year":"2001","journal-title":"Hepatology"},{"key":"10.1002\/jgm.2872-BIB0030|jgm2872-cit-0031","doi-asserted-by":"crossref","first-page":"6812","DOI":"10.4049\/jimmunol.166.11.6812","article-title":"CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells","volume":"166","author":"Schwabe","year":"2001","journal-title":"J Immunol"},{"key":"10.1002\/jgm.2872-BIB0031|jgm2872-cit-0032","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1002\/jgm.2872-BIB0032|jgm2872-cit-0033","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0232-1513(88)80155-5","article-title":"Thioacetamide-induced cirrhosis-like liver lesions in rats - usefulness and reliability of this animal model","volume":"34","author":"Muller","year":"1988","journal-title":"Exp Pathol"},{"key":"10.1002\/jgm.2872-BIB0033|jgm2872-cit-0034","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/hep.510240221","article-title":"Inhibition of experimentally induced cirrhosis in rats by hypothyroidism","volume":"24","author":"Oren","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/jgm.2872-BIB0034|jgm2872-cit-0035","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1053\/gast.2003.50063","article-title":"Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat","volume":"124","author":"Iimuro","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1002\/jgm.2872-BIB0035|jgm2872-cit-0036","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/hep.20683","article-title":"Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism","volume":"41","author":"Galli","year":"2005","journal-title":"Hepatology"},{"key":"10.1002\/jgm.2872-BIB0036|jgm2872-cit-0037","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1074\/jbc.270.11.5872","article-title":"Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3\/4- and 1\/4-length fragments","volume":"270","author":"Aimes","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1002\/jgm.2872-BIB0037|jgm2872-cit-0038","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1074\/jbc.272.4.2446","article-title":"Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules","volume":"272","author":"Ohuchi","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1002\/jgm.2872-BIB0038|jgm2872-cit-0039","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0945-053X(99)00032-3","article-title":"Collagen breakdown in soft connective tissue explants is associated with the level of active gelatinase A (MMP-2) but not with collagenase","volume":"18","author":"Kerkvliet","year":"1999","journal-title":"Matrix Biol"},{"key":"10.1002\/jgm.2872-BIB0039|jgm2872-cit-0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2007.09.008","article-title":"Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis","volume":"280","author":"Bathgate","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"10.1002\/jgm.2872-BIB0040|jgm2872-cit-0041","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1002\/jgm.2872-BIB0041|jgm2872-cit-0042","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/gut.49.4.577","article-title":"Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo","volume":"49","author":"Williams","year":"2001","journal-title":"Gut"},{"key":"10.1002\/jgm.2872-BIB0042|jgm2872-cit-0043","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0006-2952(03)00403-9","article-title":"Inhibition of markers of hepatic stellate cell activation by the hormone relaxin","volume":"66","author":"Bennett","year":"2003","journal-title":"Biochem Pharmacol"}],"container-title":["The Journal of Gene Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgm.2872","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jgm.2872\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T19:03:46Z","timestamp":1654110226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgm.2872"}},"subtitle":["Fibrinolysis by single adenoviral relaxin delivery"],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":42,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2016,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jgm.2872","archive":["Portico"],"relation":{},"ISSN":["1099-498X"],"issn-type":[{"value":"1099-498X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}