{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:25:46Z","timestamp":1773289546047,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Clinical Specialty (Ophthalmology), Zhejiang Provincial Natural Science Foundation of China","award":["LY15H120003 to YW"],"award-info":[{"award-number":["LY15H120003 to YW"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LR13H120001 to ZBJ"],"award-info":[{"award-number":["LR13H120001 to ZBJ"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371059 to ZBJ"],"award-info":[{"award-number":["81371059 to ZBJ"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Basic Research Program","award":["2013CB967502 to ZBJ"],"award-info":[{"award-number":["2013CB967502 to ZBJ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Complement factor H (CFH) related proteins (CFHRs) play important roles in complement activation pathways, whereas previous studies have only shown that CFH can affect the development of uveitis. In the present study, we investigated the potential associations between one of single\u2010nucleotide polymorphisms in the <jats:italic>CFHR<\/jats:italic>2 gene with acute anterior uveitis (AAU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 571 subjects, 283 patients diagnosed with AAU and 288 healthy adult controls, were recruited for this case\u2013control study. <jats:italic>CFHR<\/jats:italic>2\u2010rs2986127 was detected using Sequenom MassARRAY technology (Sequenom, San Diego, CA, USA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The stratified analyses for AAU patients with ankylosing spondylitis (AS) revealed a reduced frequency of the A allele in <jats:italic>CFHR<\/jats:italic>2\u2010rs2986127 compared to controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.033, odds ratio\u2009=\u20090.563, 95% confidence interval\u2009=\u2009330\u20130.960). Further stratified analyses revealed a similar significantly reduced frequency in male AAU patients with AS compared to male controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.036, odds ratio\u2009=\u20090.514, 95% confidence interval\u2009=\u20090.274\u20130.965) and in AAU patients without posterior segment involvement compared to controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study reveals an association between <jats:italic>CFHR<\/jats:italic>2\u2010rs2986127 and AAU diagnosis, especially with respect to gender, AS status and other clinical signs, such as posterior segment involvement. Our results may further enrich the growing understanding of uveitis genetics, and raise the clinical diagnostic accuracy of this disease. 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