{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:15:30Z","timestamp":1768439730849,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,30]],"date-time":"2016-10-30T00:00:00Z","timestamp":1477785600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Major science and technology research projects of Xizang (Tibet) Autonomous Region","award":["2015XZ01G23"],"award-info":[{"award-number":["2015XZ01G23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The number of heroin addicts is increasing in the world. Both environmental and genetic factors both play critical roles in the process of heroin addiction. We aimed to investigate the associations between single nucleotide polymorphisms (SNPs) in <jats:italic>LIN7C, BDNFOS<\/jats:italic> and <jats:italic>BDNF<\/jats:italic> genes and drug addiction in the Han Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a case\u2013control study among 692 cases and 700 healthy controls from Xi'an, China. Eight SNPs were selected and genotyped using MassARRAY technology (Sequenom, San Diego, CA, USA). Odds ratios (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusting for age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using the chi\u2010squared test, we found that rs7481311 (OR =1.275, 95% CI\u00a0=\u00a01.087\u20131.497, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009) and rs11030096 (OR =1.227, 95% CI\u00a0=\u00a01.049\u20131.436, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011) in the <jats:italic>BNDFOS<\/jats:italic> were associated with an increased risk of heroin addiction. By contrast, rs988712 located in <jats:italic>BDNFOS<\/jats:italic> showed a decreased risk of heroin addiction (OR =0.734, 95% CI\u00a0=\u00a00.582\u20130.925, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). By genetic model analysis, we found that the \u2018T\u2019 allele of rs988712 in <jats:italic>BDNFOS<\/jats:italic> had a protective role for heroin addiction in the additive model and dominant model (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). By contrast, the allele \u2018T\u2019 of rs7481311 in <jats:italic>BDNFOS<\/jats:italic> significantly elevated the risk of heroin addiction in the additive model, recessive model and dominant model (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). We also found that allele \u2018C\u2032 of rs11030096 was associated with an increased risk of addiction in the dominant model and additive model (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Additionally, we found that rs6265, rs11030104 and rs10767664 in <jats:italic>BDNF<\/jats:italic> were associated with a decreased risk of heroin addiction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). However, only rs7481311 in <jats:italic>BDNFOS<\/jats:italic> remained significant after Bonferroni correction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00625).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that polymorphisms of <jats:italic>BDNFOS<\/jats:italic> play an important role in heroin addiction susceptibility in the Chinese Han population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.2927","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:56:36Z","timestamp":1474332996000},"page":"288-293","source":"Crossref","is-referenced-by-count":13,"title":["The relationship between polymorphisms of <i>BDNFOS<\/i> and <i>BDNF<\/i> genes and heroin addiction in the Han Chinese population"],"prefix":"10.1002","volume":"18","author":[{"given":"Tianbo","family":"Jin","sequence":"first","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine Xizang Minzu University  Xianyang Shaanxi China"},{"name":"Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine Xizang Minzu University  Xianyang Shaanxi China"},{"name":"Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine Xizang Minzu University  Xianyang Shaanxi China"},{"name":"Xi'an Tiangen Precision Medical Institute, Xi'an  Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Forensic Science and Medicine, Xi'an Jiaotong University, Xi'an  Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Forensic Science and Medicine, Xi'an Jiaotong University, Xi'an  Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University  Hohhot Inner Mongolia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongri","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Xi'an Tiangen Precision Medical Institute, Xi'an  Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Xi'an Tiangen Precision Medical Institute, Xi'an  Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Xi'an Tiangen Precision Medical Institute, Xi'an  Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Forensic Science and Medicine, Xi'an Jiaotong University, Xi'an  Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Forensic Science and Medicine, Xi'an Jiaotong University, Xi'an  Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongya","family":"Yuan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine Xizang Minzu University  Xianyang Shaanxi China"},{"name":"Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine Xizang Minzu University  Xianyang Shaanxi China"},{"name":"Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine Xizang Minzu University  Xianyang Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2006.00012.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.S2.1085"},{"key":"e_1_2_6_4_1","first-page":"40","volume-title":"Young Adult Mental Health","author":"Reynolds EK","year":"2010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1583"},{"key":"e_1_2_6_6_1","first-page":"303","article-title":"Drug addiction. 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