{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:42:28Z","timestamp":1787730148958,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Isfahan University of Medical Sciences Deputy of Research","award":["192142"],"award-info":[{"award-number":["192142"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Selenoprotein P (SeP) is involved in transporting selenium from the liver to target tissues. Because SeP confers protection against disease by reducing chronic oxidative stress, the present study aimed to assess the level of SeP in the serum of patients with metabolic syndrome (MetS) with a history of cardiovascular disease (CVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted in 63 and 71 subjects with and without MetS in the presence of documented CVD. All demographic, anthropometric and cardiometabolic variables (lipids, blood glucose, blood pressure) were assessed. Lifestyle\u2010related factors and personal history and familial CVD risk factors were recorded. The expression of SELP in mRNA and protein levels in the serum was measured, and MetS was determined using ATPIII criteria. Binary logistic regression analysis demonstrated MetS and SeP to be dependent and independent variables, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean of systolic and diastolic blood pressure, triglyceride, high\u2010density lipoprotein\u2010cholesterol, fasting blood sugar, body mass index and waist circumference were higher among subjects with MetS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.05). The mean of selenium was higher among subjects with MetS, whereas the mean of SeP was lower among subjects with MetS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In the unadjusted model, the SeP had decreased odds for MetS [odds ratio (OR)\u00a0=\u00a00.995; 95% confidence interval (CI)\u00a0=\u00a00.989\u20131.00] (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.04). Furthermore, the association between MetS and SeP levels remained marginally significant even after adjusting for potential confounders such as age, gender, family history, smoking status and nutrition. SeP and waist circumference show a significant relationship (OR =0.995; 95% CI\u00a0=\u00a00.990\u20131.00) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have demonstrated a significant decrease in circulating SeP levels according to MetS status in patients with documented cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.2945","type":"journal-article","created":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T14:12:44Z","timestamp":1486822364000},"source":"Crossref","is-referenced-by-count":23,"title":["Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study"],"prefix":"10.1002","volume":"19","author":[{"given":"Mojgan","family":"Gharipour","sequence":"first","affiliation":[{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute Isfahan University of Medicine Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Behmanesh","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology Medical School Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoo","family":"Dianatkhah","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute Isfahan University of Medicine Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaghayegh","family":"Haghjoo Javanmard","sequence":"additional","affiliation":[{"name":"Applied Physiology Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouzbeh","family":"Razavi","sequence":"additional","affiliation":[{"name":"School of Information and Communication Technology Griffith University, Nathan Campus  Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Gharipour","sequence":"additional","affiliation":[{"name":"School of Information and Communication Technology Griffith University, Nathan Campus  Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"65","volume-title":"Molecular Mechanisms in Spermatogenesis","author":"Boitani C","year":"2008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4145"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.174"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735410367648"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220127"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.10.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.2.395"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1726"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-0134(93)85003-Q"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-7-21"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2136"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045269"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.864"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1437"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.156645"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/43.11.2183"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.47.346"},{"key":"e_1_2_6_19_1","first-page":"121","article-title":"Assessment of antioxidant nutrient intake of a population of southern US African\u2010American and Caucasian women of various ages when compared to dietary reference intakes","volume":"7","author":"Lewis S","year":"2002","journal-title":"J Nutr Health Aging"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks596"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-7-33"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1517S"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(94)90014-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.03.152"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-7-38"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.09.015"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1735-2746-9-11"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.479386"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.45"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.1.138"},{"key":"e_1_2_6_31_1","first-page":"403","article-title":"Sex\u2010specific and inter\u2010individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P","volume":"29","author":"Hybsier S","year":"2016","journal-title":"Redox Biol"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1579\/0044-7447(2007)36[94:SGAH]2.0.CO;2"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.21.2335"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2010.09.005"},{"key":"e_1_2_6_35_1","first-page":"339","article-title":"Serum trace elements in obese women with or without diabetes","volume":"137","author":"Yerlikaya FH","year":"2013","journal-title":"Indian J Med Res"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.01.005"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-4-200708210-00175"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5061937"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300755200"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.120725"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm355"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1814"}],"container-title":["The Journal of Gene Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjgm.2945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgm.2945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:11:03Z","timestamp":1696381863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgm.2945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/jgm.2945"],"URL":"https:\/\/doi.org\/10.1002\/jgm.2945","archive":["Portico"],"relation":{},"ISSN":["1099-498X","1521-2254"],"issn-type":[{"value":"1099-498X","type":"print"},{"value":"1521-2254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"article-number":"e2945"}}