{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:18:05Z","timestamp":1761920285610,"version":"3.41.2"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gestational diabetes (GDM) is carbohydrate intolerance occurring in pregnancy. Low\u2010grade inflammation plays an important role in the pathogenesis of this disorder. The present study aimed to examine the association between <jats:italic>COX2<\/jats:italic> (rs6681231) and <jats:italic>NOS3<\/jats:italic> (rs1799983 and rs2070744) gene polymorphisms and GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance. The diagnosis of GDM was based on a 75\u2010g oral glucose tolerance test at 24\u201328\u00a0weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed an increased frequency of <jats:italic>COX2<\/jats:italic> rs6681231 CC and GC genotype carriers among women with GDM (CC\u00a0+\u00a0GC versus GG, odds ratio\u00a0=\u00a01.55, 95% confidence interval\u00a0=\u00a01.01\u20132.36, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.043; C versus G, odds ratio\u00a0=\u00a01.59, 95% confidence interval\u00a0=\u00a01.10\u20132.30, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013). There were no statistically significant differences in the distribution of <jats:italic>NOS3<\/jats:italic> rs1799983 and rs2070744 between GDM and healthy women. Moreover, among women treated with insulin, we observed an increased frequency of <jats:italic>COX2<\/jats:italic> rs6681231 CC and <jats:italic>NOS3<\/jats:italic> rs1799983 TT genotype carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of the present study suggest that the CC genotype of the <jats:italic>COX2<\/jats:italic> rs6681231 polymorphism is associated with an increased risk of GDM and the need for insulin therapy, whereas the TT genotype of the <jats:italic>NOS3<\/jats:italic> rs1799983 polymorphism may be associated with the need for insulin therapy in women with GDM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.2959","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T10:14:41Z","timestamp":1493979281000},"source":"Crossref","is-referenced-by-count":4,"title":["<i>COX2<\/i> and <i>NOS3<\/i> gene polymorphisms in women with gestational diabetes"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-5077","authenticated-orcid":false,"given":"Maciej","family":"Tarnowski","sequence":"first","affiliation":[{"name":"Department of Physiology Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tkacz","sequence":"additional","affiliation":[{"name":"Department of Physiology Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violetta","family":"Dziedziejko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Safranow","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry Pomeranian Medical University  Szczecin 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