{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T12:56:45Z","timestamp":1771678605262,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The General Program of National Natural Science Foundation of China","award":["31671307"],"award-info":[{"award-number":["31671307"]}]},{"name":"Young Program of the National Natural Science Foundation of China","award":["81602745"],"award-info":[{"award-number":["81602745"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The human major histocompatibility complex (MHC) is known to be highly polymorphic and has been identified to be associated with numerous diseases. The <jats:italic>HLA\u2010DPB1<\/jats:italic> and <jats:italic>BTNL2<\/jats:italic> genes were associated with psoriasis for the first time. The present study aims to investigate the relevance of the <jats:italic>HLA\u2010DPB1<\/jats:italic> and <jats:italic>BTNL2<\/jats:italic> genes with respect to clinical phenotypes of psoriasis vulgaris (PV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To investigate whether the <jats:italic>HLA\u2010DPB1<\/jats:italic> and <jats:italic>BTNL2<\/jats:italic> polymorphisms were associated with clinical phenotypes of PV in Chinese Han population, we conducted an analysis in case\u2013controls and case\u2010only subjects (9906 controls and 8744 cases) via MHC targeted sequencing stratified analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In cases and controls, analysis showed that the genotype of <jats:italic>HLA\u2010DPB1*05:01<\/jats:italic> was associated with type of guttate [<jats:italic>p<\/jats:italic>\u00a0=\u00a03.914\u00a0\u00d7\u00a010<jats:sup>\u22122<\/jats:sup>, odds ratio (OR\u00a0=\u00a00.9335)] and northern region (<jats:italic>p<\/jats:italic>\u00a0=\u00a01.182\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>, OR\u00a0=\u00a00.9108). In the case\u2010only analysis, the genotype of <jats:italic>HLA\u2010DPB1*05:01<\/jats:italic> was significantly correlated with geographical region (<jats:italic>p<\/jats:italic>\u00a0=\u00a01.36\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>, OR\u00a0=\u00a01.134). In cases and controls, analysis showed that the genotype of <jats:italic>BTNL2<\/jats:italic> (rs 41355746) was associated with being male (<jats:italic>p<\/jats:italic>\u00a0=\u00a02.563\u00a0\u00d7\u00a010<jats:sup>\u22122<\/jats:sup>, OR\u00a0=\u00a00.8897), early\u2010onset (<jats:italic>p<\/jats:italic>\u00a0=\u00a09.399\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>, OR\u00a0=\u00a00.8856), guttate (<jats:italic>p<\/jats:italic>\u00a0=\u00a02.469\u00a0\u00d7\u00a010<jats:sup>\u22122<\/jats:sup>, OR\u00a0=\u00a00.8558) and family history (<jats:italic>p<\/jats:italic>\u00a0=\u00a01.51\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>, OR\u00a0=\u00a00.772). In the case\u2010only analysis, the genotype of <jats:italic>BTNL2<\/jats:italic> (rs41355746) was significantly correlated with family history (<jats:italic>p<\/jats:italic>\u00a0=\u00a01.768\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup>, OR\u00a0=\u00a00.757) and age of onset (<jats:italic>p<\/jats:italic>\u00a0=\u00a03.818\u00a0\u00d7\u00a010<jats:sup>\u22122<\/jats:sup>, OR\u00a0=\u00a01.195).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of the present study indicate that the <jats:italic>HLA\u2010DPB1*05:01<\/jats:italic> gene was associated with the geographical region of PV and the <jats:italic>BTNL2<\/jats:italic> gene was significantly associated with family history and age of onset of PV. In conclusion, the <jats:italic>HLA\u2010DPB1*05:01<\/jats:italic> and BTNL2 genes might be responsible for the complicacy of clinical features.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.2961","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T11:03:13Z","timestamp":1496660593000},"source":"Crossref","is-referenced-by-count":7,"title":["Correlation analysis of the <i>HLA\u2010DPB1*05:01<\/i> and <i>BTNL2<\/i> genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population"],"prefix":"10.1002","volume":"19","author":[{"given":"Huimin","family":"Guo","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology the first Affiliated Hospital Anhui Medical University  Hefei Anhui China"},{"name":"Key Laboratory of Dermatology Anhui Medical University, Ministry of Education  Hefei 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