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Currently, nucleic acid medicines, including DNAs encoding therapeutic or destructive proteins, small interfering RNAs or microRNAs, have been successfully delivered to the CNS with gene delivery vectors using various routes of administration and have subsequently exhibited remarkable therapeutic efficiency. Among these vectors, non\u2010viral vectors are favorable for delivering genes into the CNS as a result of their many special characteristics, such as low toxicity and pre\u2010existing immunogenicity, high gene loading efficiency and easy surface modification. 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