{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:00:34Z","timestamp":1760731234885,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital talipes equinovarus (CTEV) is the most common congenital deformity in children, and muscular dysplasia plays a potential role in the etiology of CTEV. Notably, previous studies have found that <jats:italic>HOXA9<\/jats:italic> rs3801776 and <jats:italic>TPM2<\/jats:italic> rs2025126 genetic polymorphisms play important roles in regulating muscle development in Caucasian children; however, there is a lack of investigations conducted in Chinese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a hospital\u2010based, case\u2013control study of 189 children with CTEV and 457 CTEV\u2010free children aiming to examine the associations between these two polymorphisms and CTEV susceptibility. The rs3801776 (G&gt;A) and rs2025126 (G&gt;A) polymorphisms were genotyped using TaqMan. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure the associations between the selected polymorphisms and CTEV susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that rs3801776A was associated with increased CTEV risk (GA versus GG: adjusted OR\u00a0=\u00a01.81, 95% CI\u00a0=\u00a01.22\u20132.69, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0031; AA versus GG: adjusted OR\u00a0=\u00a02.19, 95% CI\u00a0=\u00a01.28\u20133.73, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0041; GA\/AA versus GG: adjusted OR\u00a0=\u00a01.89, 95% CI\u00a0=\u00a01.29\u20132.76, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0010). In a stratified analysis, the risk effect of rs3801776 GA\/AA was observed in both unilateral and bilateral patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggests that the rs3801776 G&gt;A polymorphism is associated with CTEV risk in Chinese children; however, this conclusion should be validated in larger studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3119","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T11:55:13Z","timestamp":1566215713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>HOXA9<\/i> rs3801776 G&gt;A polymorphism increases congenital talipes equinovarus risk in a Chinese population"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7195-0335","authenticated-orcid":false,"given":"Jingchun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Paediatric Orthopaedics, Guangzhou Women and Children's Medical Centre Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3160-0274","authenticated-orcid":false,"given":"Jianping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Paediatric Orthopaedics, Guangzhou Women and Children's Medical Centre Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5284-2144","authenticated-orcid":false,"given":"Yanhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Paediatric Orthopaedics, Guangzhou Women and Children's Medical Centre Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0837-4942","authenticated-orcid":false,"given":"Yiqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Paediatric Orthopaedics, Guangzhou Women and Children's Medical Centre Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-1851","authenticated-orcid":false,"given":"Zhilan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Guangzhou Institute of Paediatrics Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-0176","authenticated-orcid":false,"given":"Xiaoling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Guangzhou Institute of Paediatrics Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-4072","authenticated-orcid":false,"given":"Yaping","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Guangzhou Institute of Paediatrics Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3157-2514","authenticated-orcid":false,"given":"Hongwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Paediatric Orthopaedics, Guangzhou Women and Children's Medical Centre Guangzhou Medical University  Guangzhou Guangdong 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