{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:27:19Z","timestamp":1758479239155,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30971586","81371499"],"award-info":[{"award-number":["30971586","81371499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tourette syndrome (TS) is a complex neuropsychiatric disorder coupled with obvious genetic heterogeneity. Studies in recent years have confirmed the association of <jats:italic>SLITRK<\/jats:italic> genes with sensory and neuropsychiatric diseases. To detect whether <jats:italic>SLITRK6<\/jats:italic> is involved in the progress of TS, a family\u2010based association study was performed to explore the possible genetic association between <jats:italic>SLITRK6<\/jats:italic> and TS in the Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We genotyped 399 TS nuclear families trios, and then analyzed three tag <jats:italic>SLITRK6<\/jats:italic> single nucleotide polymorphisms using the transmission disequilibrium test (TDT) haplotype relative risk (HRR) and haplotype\u2010based haplotype relative risk (HHRR) methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The TDT showed no statistically significant allele transfer for the three polymorphisms. The HRR and HHRR also showed a negative association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the results suggesting that these polymorphisms may not be associated with susceptibility to TS in the Chinese Han population, we are still unable to determine the potential role of <jats:italic>SLITRK6<\/jats:italic> in the pathogenesis of TS. Furthermore, the results still need to be confirmed in a larger sample size and in different populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3173","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T01:24:35Z","timestamp":1581297875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of <i>SLITRK6<\/i> in the pathogenesis of Tourette syndrome: From the conclusion of a family\u2010based study in the Chinese Han population"],"prefix":"10.1002","volume":"22","author":[{"given":"Wenmiao","family":"Liu","sequence":"first","affiliation":[{"name":"Medical Genetics Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"},{"name":"The Prenatal diagnosis center The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuzhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Heze Municipal Hospital  Heze Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Heze Municipal Hospital  Heze Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Genetics Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"},{"name":"The Prenatal diagnosis center The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The women and children's Hospital of Qingdao  Qingdao Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyuan","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Neurology the Affiliated Linyi People's Hospital of Shandong University  Linyi Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Genetics Department The Affiliated Hospital of Qingdao University  Qingdao Shandong China"},{"name":"The Prenatal diagnosis center The Affiliated Hospital of Qingdao University  Qingdao Shandong 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