{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:48:44Z","timestamp":1761709724592,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009334","name":"Pearl River S and T Nova Program of Guangzhou","doi-asserted-by":"publisher","award":["201710010086"],"award-info":[{"award-number":["201710010086"]}],"id":[{"id":"10.13039\/501100009334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatoblastoma is a rare malignancy originating from pluripotent stem cells with unknown etiology. An understanding of the etiology in pediatric hepatoblastoma has been hampered by the unavailability of sufficient patient samples. To date, only a few epidemiological studies with small sample sizes have been performed investigating risk factors for hepatoblastoma. <jats:italic>TP53<\/jats:italic> and <jats:italic>pri\u2010miR\u201034b\/c<\/jats:italic> genes are implicated in the tumorigenesis, yet the role of their polymorphisms in hepatoblastoma susceptibility remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a seven\u2010center case\u2013control study to explore the genetic variants predisposing to hepatoblastoma susceptibility. In our study, we genotyped two functional polymorphisms, the <jats:italic>TP53<\/jats:italic> rs1042522 C&gt;G (Arg72Pro) and <jats:italic>miR\u201034b\/c<\/jats:italic> rs4938723 T&gt;C, in 313 cases and 1446 controls using the TaqMan method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Single loci analysis showed that neither <jats:italic>TP53<\/jats:italic> rs1042522 C&gt;G, nor <jats:italic>miR\u201034b\/c<\/jats:italic> rs4938723 T&gt;C significantly modified hepatoblastoma risk. In the stratification analysis, we identified that the <jats:italic>miR\u201034b\/c<\/jats:italic> rs4938723 TC\/CC genotypes were associated with a decreased risk in patients with clinical stages III + IV hepatoblastoma (adjusted odds ratio = 0.53, 95% confidence interval = 0.33\u20130.84, <jats:italic>P<\/jats:italic>=0.007] compared to the rs4938723 TT genotype. Subsequent analysis further showed that the combination of <jats:italic>TP53<\/jats:italic> and <jats:italic>miR\u201034b\/c<\/jats:italic> variant genotypes had no impact on susceptibility hepatoblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together, <jats:italic>TP53<\/jats:italic> rs1042522 C&gt;G and <jats:italic>miR\u201034b\/c<\/jats:italic> rs4938723 T&gt;C may not confer hepatoblastoma susceptibility. These findings may aid in our understanding of the genetic etiology of hepatoblastoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3182","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:49:15Z","timestamp":1584060555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of <i>TP53<\/i> rs1042522 C&gt;G and <i>miR\u201034b\/c<\/i> rs4938723 T&gt;C polymorphisms with hepatoblastoma susceptibility: A seven\u2010center case\u2013control study"],"prefix":"10.1002","volume":"22","author":[{"given":"Peng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care Unit the First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0142-4086","authenticated-orcid":false,"given":"Zhen\u2010Jian","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Department of Clinical Laboratory, Biobank Harbin Medical University Cancer Hospital  Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Shengjing Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijuan","family":"Xin","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Medicine Center of PLA, Xijing Hospital Air Force Medical University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Children Hospital and Women Health Center of Shanxi  Taiyuan Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Kunming Key Laboratory of Children Infection and Immunity, Yunnan Key Laboratory of Children's Major Disease Research Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children's Hospital  Kunming Yunnan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Hunan Children's Hospital  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit the First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-2892","authenticated-orcid":false,"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2016.12.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890901)64:5<1082::AID-CNCR2820640520>3.0.CO;2-G"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.05.011"},{"key":"e_1_2_7_5_1","first-page":"288","article-title":"Recent incidences and trends of childhood malignant solid tumors in Shanghai, 2002\u20102010","volume":"51","author":"Bao PP","year":"2013","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_7_6_1","unstructured":"MusickSR BabikerHM.Cancer Hepatoblastoma. 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