{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:10:33Z","timestamp":1761948633936,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010360"],"award-info":[{"award-number":["2019A1515010360"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatoblastoma is a commonly occurring embryonal tumors in children. N6\u2010methyladenosine (m<jats:sup>6<\/jats:sup>A) plays a critical role in gene expression, thus contributing to the occurrence and progression of cancer. RNA splicing is regulated by the nuclear m<jats:sup>6<\/jats:sup>A reader <jats:italic>YTHDC1<\/jats:italic>, yet the roles of <jats:italic>YTHDC1<\/jats:italic> polymorphisms in hepatoblastoma remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a seven\u2010center case\u2013control study to determine the association between <jats:italic>YTHDC1<\/jats:italic> gene polymorphisms (rs2293596 T&gt;C, rs2293595 T&gt;C and rs3813832 T&gt;C) and hepatoblastoma susceptibility. We recruited 313 hepatoblastoma patients and 1446 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant association between all of these polymorphisms and hepatoblastoma susceptibility in single locus or combined analysis. Stratification analysis revealed that rs2293596 TC\/CC genotype carriers had a higher risk of developing hepatoblastoma in the subgroup of clinical stages III + IV [adjusted odds ratio (OR) = 1.80, 95% confidence interval (CI) = 1.18\u20132.76, <jats:italic>p<\/jats:italic> = 0.007]. In addition, 3 risk genotype carriers are more likely to develop hepatoblastoma in the subgroup of clinical stages III + IV (adjusted OR = 1.80, 95% CI = 1.18\u20132.76, <jats:italic>p<\/jats:italic> = 0.007). Furthermore, false\u2010positive probability analysis was used to notarize our findings. Haplotype analysis indicated that there was no significant association between inferred haplotypes of <jats:italic>YTHDC1<\/jats:italic> gene based on observed genotypes and hepatoblastoma risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, our findings suggest that the rs2293596 T&gt;C polymorphism may contribute to hepatoblastoma susceptibly and <jats:italic>YTHDC1<\/jats:italic> gene polymorphisms may have a cumulative effect on hepatoblastoma risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3249","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T23:50:50Z","timestamp":1594079450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>YTHDC1<\/i> gene polymorphisms and hepatoblastoma susceptibility in Chinese children: A seven\u2010center case\u2013control 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Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Children Hospital and Women Health Center of Shanxi  Taiyuan Shannxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijuan","family":"Xin","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Medicine Center of PLA, Xijing Hospital Air Force Medical University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong 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