{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:17:07Z","timestamp":1785845827522,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007635","name":"National Academy of Sciences of Belarus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:italic>AGER<\/jats:italic> gene encodes a cell surface multiligand receptor of advanced glycation end\u2010products that is also capable of binding other molecules and is involved in numerous pathways related to inflammation, apoptosis, immunity and so on. In the present study, we aimed to investigate whether the <jats:italic>AGER<\/jats:italic> rs1035798 (G&gt;A) intronic polymorphism, showing an association with multiple sclerosis and rheumatoid arthritis in adults, is related to juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Caucasian children from the Belarusian population were enrolled in the study. In total, there were 201 cases with JIA, 37 with juvenile systemic lupus erythematosus, 222 children with the articular syndrome of non\u2010autoimmune etiology (positive control for JIA) and 365 negative controls (children without any autoimmune or inflammatory diseases). Genomic DNA samples from the patients and controls were genotyped by a real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A marked association of the homozygous AA rs1035798 genotype with JIA (<jats:italic>p<\/jats:italic>\u2009=\u20095\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>) was found. Allele A was also associated with JIA (<jats:italic>p<\/jats:italic>\u2009=\u20090.0058), as well as with the articular syndrome of non\u2010autoimmune etiology (<jats:italic>p<\/jats:italic>\u2009=\u20090.0264). The highest frequencies of the AA genotype were found in the subgroups of JIA patients with polyarthritis or severe oligoarthritis. The AA genotype patients also had the smallest mean age of the JIA onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that the <jats:italic>AGER<\/jats:italic> rs1035798 AA genotype is a risk factor for JIA in Belarusian children. They also suggest a link between the <jats:italic>AGER<\/jats:italic> AA genotype and the risk of JIA early onset and severity. However, the functional relevance of the rs1035798 polymorphism is still unclear.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3399","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T01:43:15Z","timestamp":1637545395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>AGER<\/i> gene variant as a risk factor for juvenile idiopathic arthritis"],"prefix":"10.1002","volume":"24","author":[{"given":"Ivan Yurievich","family":"Bakutenko","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Basis of Genome Stability, Institute of Genetics and Cytology National Academy of Sciences of Belarus  Minsk Republic of Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena Dmitrievna","family":"Haurylchyk","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Basis of Genome Stability, Institute of Genetics and Cytology National Academy of Sciences of Belarus  Minsk Republic of Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Vladimirovna","family":"Sechko","sequence":"additional","affiliation":[{"name":"1<sup>st<\/sup> Department of Childhood Diseases Belarusian State Medical University  Minsk Republic of Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei Mihajlovich","family":"Tchitchko","sequence":"additional","affiliation":[{"name":"1<sup>st<\/sup> Department of Childhood Diseases Belarusian State Medical University  Minsk Republic of Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina Mihajlovna","family":"Batyan","sequence":"additional","affiliation":[{"name":"1<sup>st<\/sup> Department of Childhood Diseases Belarusian State Medical University  Minsk Republic of Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Vasil'evich","family":"Sukalo","sequence":"additional","affiliation":[{"name":"1<sup>st<\/sup> Department of Childhood Diseases Belarusian State Medical University  Minsk Republic of Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-9722","authenticated-orcid":false,"given":"Nadezhda Ivanovna","family":"Ryabokon","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Basis of Genome Stability, Institute of Genetics and Cytology National Academy of Sciences of Belarus  Minsk Republic of Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12395"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102469"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.621854"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/403460"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2067353"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.4272"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236921"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-019-00384-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.06.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2017.03.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134475"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22112"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.395"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144893"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.916260"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5473"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-019-00562-x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2119\/2007-00123.Lee"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312444495"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.09.003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.10.004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.121"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34429"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"issue":"2","key":"e_1_2_9_26_1","first-page":"390","article-title":"International League of Associations for Rheumatology. 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