{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:47:01Z","timestamp":1783810021704,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several types of polymorphisms in vitamin D receptor (VDR) have been found in psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study looked at the role of the TaqI polymorphism in the VDR gene as a factor in changing plasma 25\u2010hydroxyvitamin D [25(OH)D] levels in psoriasis patients and to see if it had any relationship with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Clinical examination, serum 25(OH)D level measurement, molecular studies and TaqI genotyping by PCR and RFLP were performed for the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The T\/t genotypes of TaqI polymorphism genotypes were most common in patients, while the t\/t genotypes were more abundant in healthy subjects. The T allele was high in the patient group in comparison with the normal subjects, but there were no significant differences (<jats:italic>p<\/jats:italic>\u00a0=\u20090.421). Patients with T\/t TaqI genotypes had higher levels of 25(OH)D than those with T\/T and t\/t (<jats:italic>p<\/jats:italic>\u00a0=\u20090.004). Moderate psoriatic patients with the T\/t genotype had relatively high 25(OH)D levels compared with moderate patients with the T\/t and t\/t genotypes (<jats:italic>p<\/jats:italic>\u00a0=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increase in 25(OH)D titers in moderate patients is greater than that in mild and severe patients. T\/t genotypes are associated with increased 25(OH)D levels in moderate and mild patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3449","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T19:03:27Z","timestamp":1663268607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["TaqI polymorphism T\/t genotypes at the vitamin D receptor gene (VDR) are associated with increased serum vitamin D levels in mild and moderate psoriasis vulgaris: A pilot study"],"prefix":"10.1002","volume":"24","author":[{"given":"Ahmed Ibrahim","family":"AbdElneam","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Department of Basic Medical Sciences, College of Medicine Shaqra University  Dawadmi Saudi Arabia"},{"name":"Molecular Genetics and Enzymology Department, Human Genetics and Genome Research Institute National Research Center  Cairo 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