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However, the molecular characteristics of the histological patterns in LUAD and the underlying molecular evolutionary mechanisms between the histological patterns in primary tumors and lymph node metastases are poorly understood. Here, we re\u2010analyzed the large TCGA\u2010LUAD dataset and depicted a comprehensive profiling of the genome and transcriptome across the histological patterns in LUAD. Tumor phylogenetic trajectory analysis suggested that the complex glands is more apt to metastasize to the lymph node. Further deconvolution of the tumor microenvironment demonstrated that the complex glands had a higher infiltration of cancer\u2010associated fibroblasts (CAFs). Single\u2010cell transcriptome profiling of complex glands pattern identified a novel CAF subtype co\u2010expressing fibroblast activation protein\u2010alpha (FAP) and stimulator of interferon genes (STING). Moreover, our data demonstrated that FAP is an important downstream effector of STING in CAFs. In summary, our results provide the basis for the development of innovative therapeutic guidelines and intervention strategies for LUAD patients.<\/jats:p>","DOI":"10.1002\/jgm.3455","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T16:26:17Z","timestamp":1664900777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of the evolution trajectory and immune profiling of new histologic patterns in lung adenocarcinoma"],"prefix":"10.1002","volume":"24","author":[{"given":"Minfang","family":"Song","sequence":"first","affiliation":[{"name":"School of Life Science and Technology ShanghaiTech University  Shanghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huikang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanghai Pulmonary 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