{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:47:14Z","timestamp":1775634434415,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009103","name":"Education Department of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colony\u2010stimulating factor 3 receptor (CSF3R) has been demonstrated to be associated with various hematological tumors, especially chronic neutrophilic leukemia; however, the detailed roles of CSF3R in other cancers remain to be explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, we systematically analyzed the expression profiles of CSF3R in pan\u2010cancer by comprehensive bioinformatics databases, such as Tumor Immune Estimation Resource, version 2 (TIMER2.0), Gene Expression Profiling Interactive Analysis, version 2 (GEPIA2.0), etc. GEPIA2.0 was also used to analyze the relationship between CSF3R expression and patients' survival prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the high expression of CSF3R was associated with a poor prognosis in the brain tumor patients, such as brain lower grade glioma and glioblastoma multiforme. In addition, we further investigated the genetic mutation and DNA methylation level of CSF3R in multiple cancers. Immune infiltration analysis showed that CSF3R expression was positively correlated with a variety of tumor\u2010infiltrating immune cells in most cancers. Single cell sequencing indicated that CSF3R levels were correlated with several cancer\u2010associated pathways, such as DNA damage, cell invasion, and stemness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together, the role of CSF3R in multiple cancers might reveal its potential as a novel prognostic biomarker and therapeutic target for cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3508","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T05:57:11Z","timestamp":1680242231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Integrated transcriptome, proteome and single\u2010cell sequencing uncover the prognostic and immunological features of colony\u2010stimulating factor 3 receptor in pan\u2010cancer"],"prefix":"10.1002","volume":"25","author":[{"given":"Liying","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Third Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medicine Xizang Minzu University  Xianyang Shaanxi China"},{"name":"Department of Pathology Xiangya Changde Hospital  Changde Hunan China"},{"name":"Key Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine Xizang Minzu University  Xianyang Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Medicine Xizang Minzu University  Xianyang Shaanxi China"},{"name":"Key Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine Xizang Minzu University  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