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Viral cores are rapidly carried on microtubules away from the cell's perimeter and deeper into the cytoplasm once the virus and cell membranes fuse. Depending on the kind of exposure, patients with monkeypox may experience a febrile prodrome 5\u201313\u2009days after exposure, which frequently includes lymphadenopathy, malaise, headaches, and muscle aches. A different diagnostic approach is available for monkeypox, including histopathological analysis, electron microscopy, immunoassays, polymerase chain reaction, genome sequencing, microarrays, loop\u2010mediated isothermal amplification technology and CRISPR (i.e., \u201cclustered regularly interspaced short palindromic repeats\u201d). There are currently no particular, clinically effective treatments available for the monkeypox virus. An initial treatment is cidofovir. As a monophosphate nucleotide analog, cidofovir is transformed into an inhibitor of viral DNA polymerase by cellular kinases, which is analogous to cidofovir's function in inhibiting viral DNA synthesis. The European Medicine Agency and the Food and Drug Administration have both granted permission for IMVAMUNE, a replication\u2010deficient, attenuated third\u2010generation modified vaccinia Ankara vaccine, to be used for the prevention of smallpox and monkeypox in adults.<\/jats:p>","DOI":"10.1002\/jgm.3521","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:17:06Z","timestamp":1683094626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Monkeypox: Virology, laboratory diagnosis and therapeutic approach"],"prefix":"10.1002","volume":"25","author":[{"given":"Haleh","family":"Siami","sequence":"first","affiliation":[{"name":"School of Medicine Islamic Azad University of Medical Science  Tehran 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