{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:41:12Z","timestamp":1770352872732,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris (AV) is a chronic, multifactorial inflammatory disease of the pilosebaceous unit brought on by hormonal imbalance, excessive sebum production, follicular hyperkeratinization, inflammation and <jats:italic>Cutibacterium acne<\/jats:italic>. Acne patients are characterized by alteration of the lipid profile. Apolipoprotein B gene (ApoB) plays an essential role in lipoprotein biosynthesis and multiple single\u2010nucleotide polymorphisms (SNPs) in ApoB are associated with dyslipidemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to estimate the alteration of lipid profiles in AV, determine the genetic association with lipid profile alteration by studying the ApoB gene polymorphisms, and to identify the exact haplotypes associated with acne and lipid profile alteration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>In a case\u2013control study consisting of 63 non\u2010obese acne patients and 43 healthy controls, all participants underwent biochemical, anthropological assessments, and genetic analysis for ApoB polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Our results indicate that serum ApoB and the lipid profile were higher in acne patients compared with healthy subject. The most common haplotypes in acne patients were rs562338 A\/rs17240441 I\/c.12669 A\/rs1042034 G, whereas the most common haplotypes in healthy subjects were rs562338 G\/rs17240441 D\/c.12669 A\/rs1042034 G. Patients with mild acne had higher serum ApoB levels <jats:italic>p<\/jats:italic>\u00a0=\u20090.005. Also, the low\u2010density lipoprotein cholesterol (LDL\u2010C) level was higher in mild acne compared with other acne groups, with a highly significant variation of <jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found a significant variation between the acne group and healthy controls in serum ApoB, triglycerides, total cholesterol and LDL\u2010C. The most common haplotypes in acne patients are rs562338 A\/, rs17240441 I\/, c.12669 A\/ and rs1042034 G, and there is a linkage disequilibrium between the four selected SNPs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3578","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T04:59:05Z","timestamp":1692421145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris"],"prefix":"10.1002","volume":"26","author":[{"given":"Ahmed Ibrahim","family":"AbdElneam","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Department of Basic Medical Sciences, College of Medicine Shaqra University  Dawadmi Saudi Arabia"},{"name":"Molecular Genetics and Enzymology Department Human Genetics and Genome Research Institute, National Research Center  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-1873","authenticated-orcid":false,"given":"Ghadah","family":"Alhetheli","sequence":"additional","affiliation":[{"name":"Divisions of Dermatology and Cutaneous Surgery, College of Medicine Qassim University  Buraydah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Saleh","family":"Al\u2010Dhubaibi","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, College of Medicine Shaqra University  Dawadmi Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh Salem","family":"Bahaj","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences Sana'a University  Sana'a 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