{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:51:07Z","timestamp":1783129867690,"version":"3.54.6"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bladder cancer (BLCA) is a prevalent malignancy worldwide. Anoikis remains a new form of cell death. It is necessary to explore Anoikis\u2010related genes in the prognosis of BLCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We obtained RNA expression profiles from the The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases for dimensionality reduction analysis and isolated epithelial cells, T cells and fibroblasts for copy number variation analysis, pseudotime analysis and transcription factor analysis based on R package. We integrated machine\u2010learning algorithms to develop the artificial intelligence\u2010derived prognostic signature (AIDPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The performance of AIDPS with clinical indicators was stable and robust in predicting BLCA and showed better performance in every validation dataset compared to other models. Mendelian randomization analysis was conducted. Single nucleotide polymorphism (SNP) sites of rs3100578 (HK2) and rs66467677 (HSP90B1) exhibited significant correlation of bladder problem (not cancer) and bladder cancer, whereasSNP sites of rs3100578 (HK2) and rs947939 (BAD) had correlation between bladder stone and bladder cancer. The immune infiltration analysis of the TCGA\u2010BLCA cohort was calculated via the ESTIMATE (i.e. Estimation of STromal and Immune cells in MAlignantTumours using Expression data) algorithm which contains stromal, immune and estimate scores. We also found significant differences in the IC<jats:sub>50<\/jats:sub> values of Bortezomib_1191, Docetaxel_1007, Staurosporine_1034 and Rapamycin_1084 among the high\u2010 and low\u2010risk groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, these findings indicated Anoikis\u2010related prognostic genes in BLCA and constructed an innovative machine\u2010learning model of AIDPS with high prognostic value for BLCA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.3651","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T02:24:31Z","timestamp":1705026271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unveiling Anoikis\u2010related genes: A breakthrough in the prognosis of bladder cancer"],"prefix":"10.1002","volume":"26","author":[{"given":"Shen","family":"Jiang","sequence":"first","affiliation":[{"name":"Jilin Cancer Hospital  Changchun Jilin China"},{"name":"Department of Urology China\u2010Japan Union Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiping","family":"Yang","sequence":"additional","affiliation":[{"name":"Jilin Cancer Hospital  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lin","sequence":"additional","affiliation":[{"name":"Jilin Cancer Hospital  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Transplant Surgery Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Jia","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Transplant Surgery Ludwig\u2010Maximilians\u2010University Munich  Munich 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