{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:16:11Z","timestamp":1775081771328,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T00:00:00Z","timestamp":1082419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have shown that incubation of balloon\u2010injured rat carotid arteries with adenoviral vectors encoding the carboxyl terminus of the \u03b2\u2010adrenergic receptor kinase (Ad2\/\u03b2ARKct) for 30 min reduces neointima formation. However, it is unclear whether this beneficial effect of \u03b2ARKct could be achieved using a catheter\u2010based vector delivery system and whether the observed inhibition of neointima formation translated into a reduction of vessel stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, Ad2\/\u03b2ARKct was infused into the balloon\u2010injured site of rabbit iliac arteries using a porous infusion catheter over 2 min. Twenty\u2010eight days after gene transfer, angiographic and histological assessments were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Angiographic and histological assessments indicate significant (<jats:italic>p<\/jats:italic> &lt; 0.05) inhibition of iliac artery neointima formation and lumen stenosis by Ad2\/\u03b2ARKct. Our studies demonstrate that an inhibitory effect of Ad2\/\u03b2ARKct on neointima formation is achievable using a catheter\u2010based vector delivery system and that the inhibition of neointima formation translates into a gain in the vessel minimal luminal diameter. The extent of inhibition (35%) was comparable to that observed with adenoviral\u2010mediated expression of thymidine kinase plus ganciclovir treatment, a cytotoxic gene therapy approach for restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that adenoviral\u2010mediated gene transfer of \u03b2ARKct is a clinically viable cytostatic gene therapy strategy for the treatment of restenosis. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jgm.592","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T09:05:33Z","timestamp":1082451933000},"page":"1061-1068","source":"Crossref","is-referenced-by-count":5,"title":["Catheter\u2010mediated delivery of adenoviral vectors expressing \u03b2\u2010adrenergic receptor kinase C\u2010terminus inhibits intimal hyperplasia and luminal stenosis in rabbit iliac arteries"],"prefix":"10.1002","volume":"6","author":[{"given":"Zhengyu","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Palasis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis 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