{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:21:38Z","timestamp":1776158498608,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Preeclampsia (PE) is a common complication during pregnancy. Trophoblast cells are the main cell type of the placenta, and abnormalities in proliferation and differentiation cause anterior placental accretion and lead to the development of PE. This study will investigate the function and related mechanism of N6\u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) reader YTH N6\u2010methyladenosine RNA binding protein F3 (YTHDF3) in PE and provide a rationale for the therapeutic treatment of PE. In the study, YTHDF3 and suppressor of cytokine signaling 1 (SOCS1) expression were significantly upregulated within PE placental tissue samples.\n                    <jats:italic>YTHDF3<\/jats:italic>\n                    knockdown promoted the capacity of hypoxia\u2010treated trophoblast cells to proliferate, migrate, invade, and undergo epithelial\u2010mesenchymal transition (EMT) and inhibited apoptosis. The JAK1\/STAT3 pathway is aberrantly activated in trophoblast cells of PE. YTHDF3 binds m\n                    <jats:sup>6<\/jats:sup>\n                    A\u2010modified\n                    <jats:italic>SOCS1<\/jats:italic>\n                    mRNA to enhance its stability and translation.\n                    <jats:italic>YTHDF3<\/jats:italic>\n                    \/\n                    <jats:italic>SOCS1<\/jats:italic>\n                    promotes disease progression in PE by inhibiting the JAK1\/STAT3 signaling pathway. In conclusion, YTHDF3 promotes the disease progression of PE by enhancing the m\n                    <jats:sup>6<\/jats:sup>\n                    A modification of\n                    <jats:italic>SOCS1<\/jats:italic>\n                    mRNA and suppressing the JAK1\/STAT3 signaling pathway. YTHDF3 has been identified as an underlying target for the clinical treatment of PE.\n                  <\/jats:p>","DOI":"10.1002\/jgm.70036","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:54:56Z","timestamp":1764046496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["YTHDF3 Promotes N6\u2010Methyladenosine Modification of\n                    <i>SOCS1<\/i>\n                    to Inhibit JAK1\/STAT3 Pathway in the Pathogenesis of Preeclampsia"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-3087","authenticated-orcid":false,"given":"Shuang","family":"Sui","sequence":"first","affiliation":[{"name":"Department of Obstetrics People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi Xinjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi Xinjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi Xinjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8043-7039","authenticated-orcid":false,"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics People's Hospital of Xinjiang Uygur Autonomous Region  Urumqi Xinjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8401"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103780"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S485653"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-025-03896-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.422"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020105977"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0168-5"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-00295-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16961"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.853857"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.724741"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.313049"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.727987"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.08.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9544"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.12.001"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.05.010"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11701"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S204017441900014X"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00913-w"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.180081"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2022.02.004"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0144-4"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.ejgo.2021.03.2416"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106210"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00791-1"},{"issue":"19","key":"e_1_2_12_29_1","first-page":"6190","article-title":"Lowly Expressed EGFR\u2010AS1 Promotes the Progression of Preeclampsia by Inhibiting the EGFR\u2010JAK\/STAT Signaling Pathway","volume":"22","author":"Zhao Z. 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