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These ulcers can lead to neuropathy, vasculopathy and severe infections. LncRNAs, a class of long\u2010stranded noncoding RNAs that regulate gene expression, have been shown to play a critical regulatory role in diabetic foot ulcer wound healing. These molecules have been demonstrated to modulate numerous facets of the inflammatory response, cell proliferation and angiogenesis, which collectively influence the outcome of wound healing. A substantial body of research has emerged in recent years, highlighting the critical role of these noncoding transcripts in DFU. 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