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It is characterized by a significant likelihood of recurrence and resistance to conventional therapies and a lack of efficient screening techniques. MicroRNAs (miRNAs) are small, noncoding RNA molecules that exert pivotal functions in modulating gene expression. miRNAs are improperly regulated in OC, contributing to tumor onset, progression, metastasis, and resistance to chemotherapeutics. As a result, miRNAs are promising therapeutic targets for the treatment of OC. Recently, natural products derived from plants and other sources have drawn more interest because of their potential to modulate miRNA expression. A variety of bioactive substances, such as curcumin, quercetin, and others, have shown the ability to either promote tumor\u2010suppressing miRNAs or suppress tumor\u2010promoting miRNAs. These substances have a great deal of promise for improving the effectiveness of traditional chemotherapy, lowering adverse effects, and providing more individualized treatment plans. Additionally, their capacity to target several miRNAs implicated in cancer\u2010related pathways offers a multimodal strategy for treating OC. We can upgrade the potential therapeutic options for OC and other cancers by exploring novel natural products with miRNA\u2010modulating effects. However, further research is needed to clinically translate miRNA\u2010based therapeutics employing natural compounds, especially in the areas of safety, bioavailability, and drug delivery methods. This review emphasized the implications of miRNAs in OC, the impact of natural products on miRNA regulations, and the potential for incorporating these natural substances into clinical practice for individualized and successful OC treatments.<\/jats:p>","DOI":"10.1002\/jgm.70080","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T06:52:47Z","timestamp":1768200767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["miRNA\u2010Directed Anticancer Strategies: The Emerging Role of Natural Products in Ovarian Cancer"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-3150","authenticated-orcid":false,"given":"Rasha","family":"Abu\u2010Khudir","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science King Faisal University  Hofuf Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaza\u00a0H.","family":"Aly","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Badr University in Cairo  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal\u00a0I.","family":"Rizk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy and Drug Technology Egyptian Chinese University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-4470","authenticated-orcid":false,"given":"Rabab\u00a0S.","family":"Hamad","sequence":"additional","affiliation":[{"name":"Biological Sciences Department, College of Science King Faisal University  Al Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba\u00a0M.","family":"Midan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Badr University in Cairo  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-7617","authenticated-orcid":false,"given":"Mai\u00a0A.","family":"Abd\u2010Elmawla","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-5035","authenticated-orcid":false,"given":"Sherif\u00a0S.","family":"Abdel\u00a0Mageed","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy Badr University in Cairo  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed\u00a0I.","family":"Abulsoud","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy Heliopolis University  Cairo Egypt"},{"name":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys) Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed\u00a0Bakr","family":"Zaki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy University of Sadat City  Menoufia Egypt"},{"name":"Department of Biochemistry, Faculty of Pharmacy Menoufia National University  Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-9609","authenticated-orcid":false,"given":"Osama\u00a0A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine University of Bisha  Bisha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-755X","authenticated-orcid":false,"given":"Ahmed\u00a0E.","family":"Elesawy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Badr University in Cairo  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-8515","authenticated-orcid":false,"given":"Walaa\u00a0A.","family":"El\u2010Dakroury","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy Badr University in Cairo (BUC)  Badr City Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-7096","authenticated-orcid":false,"given":"Ahmed\u00a0S.","family":"Doghish","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Badr University in Cairo  Cairo Egypt"},{"name":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys) Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"issue":"2","key":"e_1_2_18_2_1","first-page":"93","article-title":"Epidemiology and Risk Factors for Ovarian Cancer","volume":"22","author":"Ali A. 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