{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:49:42Z","timestamp":1782208182211,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Gene Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/aim<\/jats:title>\n                    <jats:p>Recurrent miscarriage (RM) is a major reproductive concern affecting a large number of women worldwide. Genetic factors are thought to play an important role in RM. Due to its potential function in angiogenesis, the histidine\u2010rich glycoprotein (HRG) gene has become a focus of research. Therefore, the present study aimed to determine the association between the HRG A1043G single\u2010nucleotide polymorphism (SNP) and RM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>To meet the objectives of the study, 110 women with a history of RM were included. The control group consisted of 60 women who had delivered children and had no history of miscarriage. Blood samples were collected from all participants; genomic DNA was extracted and amplified using polymerase chain reaction (PCR). Sanger sequencing was performed to screen for the A1043G polymorphism in exon 7 of the HRG gene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The findings revealed a significant association between the HRG SNP and the risk of RM at both genotypic and allelic levels. Compared to the AA genotype, mutant genotypes (AG\u2009+\u2009GG) showed a significantly higher risk of RM (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041). The G allele was also significantly associated with RM, as indicated by the odds ratio (OR) analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study demonstrated that genetic variation in the HRG gene may contribute to susceptibility to RM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jgm.70100","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T03:00:51Z","timestamp":1780282851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Histidine\u2010Rich Glycoprotein A1043G Polymorphism and Susceptibility to Recurrent Miscarriage in Erbil\u2014The Kurdistan Region of Iraq"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2410-4889","authenticated-orcid":false,"given":"Narmeen Abdulsamad","family":"Ismaiel","sequence":"first","affiliation":[{"name":"Department of Biology, College of Education Salahaddin University  Erbil Kurdistan Region Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazhal Muhammad","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Education Salahaddin University  Erbil Kurdistan Region Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010023\u201001344\u20103"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107827\u201012\u201070"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead039"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/mr\u20102022\u20100030"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfnr.2022.02.002"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.26502\/fjwhd.2644-28840038"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12124074"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-93042020000200003"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa016"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.03.009"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197022"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10070522"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3422138"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112435"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.09.024"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871\u2010022\u201001774\u20107"},{"issue":"2","key":"e_1_2_13_18_1","first-page":"593","article-title":"Histidine Rich Glycoprotein and Cancer: A Multi\u2010Faceted Relationship","volume":"34","author":"Johnson L. D.","year":"2014","journal-title":"Anticancer Research"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11172684"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.005"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101711.2005.01320.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2015.0589"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090782"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2017.11.003"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.18926\/AMO\/57366"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7190828"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5nr05290d"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29312"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1342404eCollection"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12155"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-018-0550-8"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09758-1"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/2501086"},{"issue":"18","key":"e_1_2_13_34_1","first-page":"5344","article-title":"Histidine\u2010Proline\u2010Rich Glycoprotein Has Potent Antiangiogenic Activity Mediated Through the Histidine\u2010Proline\u2010Rich Domain","volume":"62","author":"Juarez J. C.","year":"2002","journal-title":"Cancer Research"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0050-5"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1315758"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1642-431X(12)60085-0"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gas017"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr027"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2012.01123.x"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903295618"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.04.004"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508483200"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom7010022"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1941"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1276588"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-010-0508-1"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-09-0094"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.07.015"}],"container-title":["The Journal of Gene Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgm.70100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jgm.70100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jgm.70100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:18:10Z","timestamp":1782206290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jgm.70100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jgm.70100"],"URL":"https:\/\/doi.org\/10.1002\/jgm.70100","archive":["Portico"],"relation":{},"ISSN":["1099-498X","1521-2254"],"issn-type":[{"value":"1099-498X","type":"print"},{"value":"1521-2254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,31]]},"assertion":[{"value":"2026-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70100"}}