{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:05Z","timestamp":1753869425135,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Existing research presents conflicting results on the influence of blood donor sex on hemoglobin (Hb) change and transfusion\u2010associated infection and mortality in transfusion recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This retrospective study explored the association between donor and recipient sex on hospital\u2010onset sepsis (HO\u2010sepsis) and Hb changes in critically ill patients receiving red blood cell (RBC) transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 2010\u20132020 were extracted from an academic hospital's clinical database and a blood supplier's donor database. HO\u2010sepsis was determined based on the International Classification of Diseases and Related Health Problems 10th Revision (ICD\u201010) diagnostic codes without requiring a microbiology test within the first 48\u00a0h of admission. Hb increments were determined by comparing the last Hb result in the 24\u2010h period prior to RBC unit issue and the first Hb result within 4\u201324\u00a0h after RBC unit issued for transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>25,585 critically ill patients received one or more RBC transfusions; 3,410 were included in the HO\u2010sepsis and 3,487 in the Hb increment analysis. There was no significant differences in the HO\u2010sepsis rate among the four groups, but female recipients were more prone to HO\u2010sepsis than males (OR 1.48, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Multivariate analysis found that the number of RBC unit transfused (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and recipient age (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), but not recipient sex (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.63), were significant contributors to HO\u2010sepsis. Male blood was associated with higher Hb than female blood in female recipients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), but not in male recipients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.75). Variables such as donor Hb levels and recipient Hb level influenced Hb increments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Blood donor sex was not associated with HO\u2010sepsis in critically ill patients receiving RBC transfusion. Male to female transfusions were associated with a higher Hb increment in recipients. Further exploration of the impact of sex mis\u2010matched transfusion on recipient outcomes is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1005","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T10:50:58Z","timestamp":1736247058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The association of donor and recipient sex on sepsis rates and hemoglobin increment among critically ill patients receiving red cell transfusions in a retrospective study"],"prefix":"10.1002","volume":"6","author":[{"given":"Wenhui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla J.","family":"Lucier","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy M.","family":"Heddle","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Innovation and Portfolio Management Canadian Blood Services  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-827X","authenticated-orcid":false,"given":"Jason P.","family":"Acker","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"},{"name":"Innovation and Portfolio Management Canadian Blood Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.17843"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000214314.57109.CD"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12712"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2012.04.001"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30169-2"},{"issue":"4","key":"e_1_2_14_7_1","first-page":"289","article-title":"Impact of G6PD status on red cell storage and transfusion outcomes","volume":"17","author":"Karafin MS","year":"2019","journal-title":"Blood Transfus"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13745"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.14825"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.23942"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101628"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.152598"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006402"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211523"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.12.1499"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13362"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16688"},{"key":"e_1_2_14_18_1","unstructured":"TinmouthA PerelmanI AckerJP Chass\u00e9M FergussonD.Assessing the impact of donor and manufacturing characteristics on hemoglobin increments following red blood cell transfusion in Canada.Vancouver: CSTM 2022 Abstract Booklet;2022."},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16939"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000261890.41311.E9"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.12927\/hcq.2010.21963"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009487"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000296070.75956.40"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1556\/EuJMI-D-14-00035"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000773"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16338"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022139"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.1005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:32:44Z","timestamp":1741761164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.1005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jha2.1005"],"URL":"https:\/\/doi.org\/10.1002\/jha2.1005","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"2024-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1005"}}