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It offers a risk\u2010adapted approach with the addition of isatuximab for genetically high\u2010risk patients, evaluated using local cytogenetics laboratories rather than centralised testing. We have observed excellent overall success rates, with\u00a0&gt;\u00a090% patients assigned to a risk\u2010adapted pathway following cytogenetic testing in 25 local laboratories nationwide, with clinically\u2010relevant turnaround times allowing\u00a0&gt;\u00a070% patients to commence isatuximab at the earliest opportunity if indicated. 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