{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:01:49Z","timestamp":1792609309377,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy is highly effective in B\u2010cell blood cancers, but there is limited data on its safety and efficacy in intra\u2010cardiac lymphoma, due to the potential risks of cardiotoxicity and pseudo\u2010progression.<\/jats:p><\/jats:sec>Discussion<\/jats:title>We discuss four high\u2010risk cases that were managed with a multi\u2010disciplinary approach, including baseline cardiac risk assessment and surveillance with multimodal cardiac imaging and serum cardiac biomarkers, elective supportive care in the intensive care unit, and early treatment of cytokine release syndrome.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CAR\u2010T therapy can be effective and safe in the treatment of B\u2010cell blood cancers with intra\u2010cardiac disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1020","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T17:15:12Z","timestamp":1729185312000},"page":"1283-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CD19\u2010targeting chimeric antigen receptor T\u2010cell therapy is safe and effective for intra\u2010cardiac B cell non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-276X","authenticated-orcid":false,"given":"Daniel H.","family":"Chen","sequence":"first","affiliation":[{"name":"University College Hospital University College London Hospitals NHS Foundation Trust London UK"},{"name":"Hatter Cardiovascular Institute University College of London London UK"},{"name":"Prince of Wales & St George Hospitals South East Sydney Local Health District Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2702-397X","authenticated-orcid":false,"given":"Maeve","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"University College Hospital University College London Hospitals NHS Foundation Trust London UK"},{"name":"University College London Cancer Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen 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