{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:38:06Z","timestamp":1768264686444,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize variations in real\u2010world treatment patterns in multiple myeloma (MM) in Portugal over a 5\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort multicenter study using secondary data of national hospital drug consumption database from 11 Portuguese public hospitals between 2017 and 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Number of MM\u2010treated patients increased 53% over 5 years (from 825 to 1266 patients). Constant slight predominance of male patients (55%), 82% over 60 years old (median age, 70 years), and half of newly diagnosed patients were transplant\u2010eligible. The highest growth rate was in second\u2010line treatments, with a sixfold increase in patients in fourth\u2010line or beyond. First\u2010line treatment pattern remained stable both in transplant\u2010eligible (bortezomib, cyclophosphamide and dexamethasone (VCd_, bortezomib, thalidomide and dexamethasone (VTd), and bortezomib, lenalidomide and dexamethasone (VRd)) and noneligible patients (bortezomib, melphalan and prednisolone (VMP), VCd, and lenalidomide, dexamethasone (Rd)). Maintenance therapy increased from 5% to 16%, shifting from thalidomide to lenalidomide. Second and third lines were dominated by daratumumab\u2010based regimens after 5 years. No standard of care in fourth\u2010line treatment. Treatment duration increased in transplant\u2010eligible due to maintenance therapy and in noneligible due to fourth\u2010line treatments. Patients moved from first\u2010 to second\u2010line more rapidly over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was an increase in MM patients reaching advanced treatment lines and significant changes in the treatment patterns, driven by access to more effective frontline treatments and longer duration of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1035","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T18:29:36Z","timestamp":1730140176000},"page":"1144-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The evolving treatment landscape of multiple myeloma in Portugal: A nation\u2010wide retrospective cohort study of real\u2010world clinical practice"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7811-9509","authenticated-orcid":false,"given":"Rui","family":"Bergantim","sequence":"first","affiliation":[{"name":"Hematology Department ULS S\u00e3o Jo\u00e3o Porto Portugal"},{"name":"i3S Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade University of Porto Porto Portugal"},{"name":"Cancer Drug Resistance Group Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) Porto Portugal"},{"name":"Clinical Hematology Department Faculty of Medicine of the University of Porto (FMUP) Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Geraldes","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department ULS Coimbra Coimbra Portugal"},{"name":"University Clinics of Hematology and Oncology and Laboratory of Oncobiology and Hematology (LOH), Faculty of Medicine University of Coimbra (FMUC) Coimbra Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR)\u2014Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine University of Coimbra (FMUC) Coimbra Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB) University of Coimbra Coimbra Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC) Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Jo\u00e3o","sequence":"additional","affiliation":[{"name":"Hemato\u2010Oncology Unit, Hematology Department Funda\u00e7\u00e3o Champalimaud Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"L\u00facio","sequence":"additional","affiliation":[{"name":"Hemato\u2010Oncology Unit, Hematology Department Funda\u00e7\u00e3o Champalimaud Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Neves","sequence":"additional","affiliation":[{"name":"Hemato\u2010Oncology Unit, Hematology Department Funda\u00e7\u00e3o Champalimaud Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Trigo","sequence":"additional","affiliation":[{"name":"Hematology Department ULS S\u00e3o Jo\u00e3o Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"IQVIA Solutions Portugal Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Ventura","sequence":"additional","affiliation":[{"name":"IQVIA Solutions Portugal Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Santos","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Innovative Medicine Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo","family":"Ramos","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson Innovative Medicine Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26590"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00165-X"},{"key":"e_1_2_13_4_1","unstructured":"GLOBOCAN 2022. [Online]. Accessed July 2024. Available from:https:\/\/gco.iarc.fr\/today\/en\/dataviz\/"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2016.11.004"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-020-00993-5"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020-0141"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-015-0826-3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020407"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01474-w"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx096"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000528"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2020.06.002"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.20344\/amp.19037"},{"key":"e_1_2_13_15_1","unstructured":"PORDATA. [Online]. Accessed July 2024. Available from:https:\/\/www.pordata.pt\/portugal\/populacao+residente+total+e+por+grandes+grupos+etarios\u2010513\u20102545"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15225338"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15436"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13026"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2023-0021"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114083"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.1143.1143"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30110705"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03640-y"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18658"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13821"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000829632.52535.d2"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14161"},{"key":"e_1_2_13_28_1","unstructured":"GLOBOCAN 2022. [Online]. Accessed July 2024. Available from:https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/620\u2010portugal\u2010fact\u2010sheet.pdf"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.1035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T12:50:06Z","timestamp":1734353406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.1035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/jha2.1035"],"URL":"https:\/\/doi.org\/10.1002\/jha2.1035","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2024-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}