{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:35:14Z","timestamp":1793907314075,"version":"4.8.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with chronic lymphocytic leukemia (CLL) are susceptible to infections that can affect their clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess: (1) the incidence of pneumonia in CLL patients treated with venetoclax\u2010based regimens in a real\u2010world setting, (2) the risk factors for event\u2010free survival (EFS), and (3) overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter study included 322 patients from eight centers. Univariable and multivariable analyses (MVA) were performed, having the development of pneumonia during venetoclax\u2010based treatment and OS as outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common complication was neutropenia (59%). During treatment with venetoclax\u2010based regimens, 66 (20%) of patients developed pneumonia: 50 (23%) patients in the rituximab plus venetoclax (R\u2010VEN) group, 13 (16%) patients in the obinutuzumab plus venetoclax (O\u2010VEN) group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.15). Chronic obstructive pulmonary disease (COPD)\/asthma, splenomegaly, elevated creatinine, and anemia &lt;8\u00a0g\/dL were the risk factors for EFS in MVA (hazard ratio [HR]\u00a0=\u00a02.08, 95% confidence interval [CI], 1.16\u20133.74, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014; HR 1.73, 95% CI, 1.08\u20132.78, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02; HR 2.13, 95% CI, 1.10\u20134.11, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03, HR 3.58, 95% CI, 2.18\u20135.89, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, respectively). Relapsed\/refractory (R\/R) CLL patients treated with R\u2010VEN with pneumonia had worse OS than those without (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In patients treated with O\u2010VEN, median OS did not differ between patients with and without pneumonia (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our real\u2010world study showed that pneumonia during venetoclax treatment occurs more frequently than reported in registration trials and has a negative impact on OS, especially in patients with R\/R CLL treated with R\u2010VEN. Neutropenia is not a risk factor for pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1042","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T11:28:52Z","timestamp":1730719732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pneumonia in patients with chronic lymphocytic leukemia treated with venetoclax\u2010based regimens: A real\u2010world analysis of Polish Adult Leukemia Group (PALG)"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-8001","authenticated-orcid":false,"given":"El\u017cbieta","family":"Kalici\u0144ska","sequence":"first","affiliation":[{"name":"Clinical Department of Hematology, Cell Therapies and Internal Diseases Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Jablonowska\u2010Babij","sequence":"additional","affiliation":[{"name":"Clinical Department of Hematology, Cell Therapies and Internal Diseases Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Morawska","sequence":"additional","affiliation":[{"name":"Experimental Hematooncology Department Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2772-8870","authenticated-orcid":false,"given":"El\u017cbieta","family":"Iskierka\u2010Ja\u017cd\u017cewska","sequence":"additional","affiliation":[{"name":"Department of General Hematology Medical University of Lodz  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Drozd\u2010Sokolowska","sequence":"additional","affiliation":[{"name":"Department of Hematology, Transplantation and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Paszkiewicz\u2010Kozik","sequence":"additional","affiliation":[{"name":"Department of Lymphoid Malignancies National Research Institute of Oncology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Szukalski","sequence":"additional","affiliation":[{"name":"Department of Hematology Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144  Toru\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judyta","family":"Strza\u0142a","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Pomeranian Hospitals in Gdynia  Gdynia Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Gosik","sequence":"additional","affiliation":[{"name":"Department of Hematology St. John's Cancer Center in Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"D\u0119bski","sequence":"additional","affiliation":[{"name":"Department of Hematology Provincial Specialist Hospital in Legnica  Legnica Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iga","family":"Andrasiak","sequence":"additional","affiliation":[{"name":"Independent Researcher  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Skotny","sequence":"additional","affiliation":[{"name":"Harvard T.H. 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