{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:55:00Z","timestamp":1793656500377,"version":"4.5.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012036","name":"Lotte Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients undergoing chimeric antigen receptor (CAR) T\u2010cell therapy face prolonged treatment timelines and are prone to cytokine release syndrome (CRS) and immune effector cell\u2010associated neurotoxicity syndrome (ICANS) after infusion. Disabilities in physical function and the importance of rehabilitation during CAR\u2010T\u2010cell therapy to maintain physical function have been poorly documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a retrospective cohort study to assess changes in exercise tolerance via differences in a 6\u2010min\u2010walking distance (\u03946MWD) and factors influencing it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 77 patients who underwent rehabilitation during CAR\u2010T\u2010cell therapy were enrolled, and their 6MWD was 450\u00a0m (median, range 180\u2013705\u00a0m) before and 450.5\u00a0m (107.0\u2013735.0\u00a0m) 30 days after CAR\u2010T treatment. No significant alteration in \u03946MWD was observed overall (11.0\u00a0m, 95% confidence interval, \u221256.1 to 88.2\u00a0m). Multiple regression analyses indicated that age (over vs. under 65 years) revealed no notable differences in \u03946MWD (20 vs. 10\u00a0m), while \u0394Hb (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.24, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), moderate\/severe CRS (grade 1 with continuous fever or grade \u22652; <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.25, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), and ICANS (any grade; <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.22, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) were significantly associated with lower \u03946MWD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This real\u2010world study indicated that CAR\u2010T\u2010cell therapy is less likely to reduce physical function even in older patients if rehabilitation is properly performed, whereas CRS and ICANS can be risk factors to deprive exercise tolerance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1043","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T11:24:43Z","timestamp":1730719483000},"page":"1252-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fluctuation of physical function during chimeric antigen receptor T\u2010cell therapy during rehabilitation intervention: Real\u2010world data and risk factor analyses"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8547-5173","authenticated-orcid":false,"given":"Ryota","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9662-5093","authenticated-orcid":false,"given":"Yasuyuki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of 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