{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:10:57Z","timestamp":1780395057158,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Enteropathy\u2010associated T\u2010cell lymphoma (EATL) is a peripheral T\u2010cell lymphoma (PTCL) with a poor prognosis. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without etoposide consolidated by autologous stem cell transplantation (ASCT) are recommended for fit PTCL patients. The role of etoposide and ASCT in EATL is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study reports the incidence, treatment, and outcome of EATL patients using the Netherlands Cancer Registry, with nationwide coverage of\u00a0&gt;95%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients diagnosed in 1989\u20132021 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0351, 77% treated) were identified (median age 67 years, 56% male, 50% limited stage). Time period analysis assessed trends in primary therapy and overall survival (OS). Treatment included chemotherapy (CT) (34%), surgery (18%), surgery and CT (19%) or CT followed by ASCT (7%). The 5\u2010year OS for treated patients with limited versus advanced stage was 19% and 9% respectively. The 2\u2010year OS improved over time (21%\u201333%, <jats:italic>p\u00a0=\u00a0<\/jats:italic>0.06). Surgery only (hazard ratio [HR] 2.16; 95% confidence interval [CI] 1.55\u20133.01, <jats:italic>p\u00a0&lt;<\/jats:italic>\u00a00.01) and advanced\u2010stage disease (HR 1.67; 95% CI 1.25\u20132.23, <jats:italic>p\u00a0=<\/jats:italic>\u00a00.01) were predictors of poor prognosis. ASCT (HR 0.31; 95% CI 0.18\u20130.56) was associated with improved OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was no statistical difference in OS between patients treated with or without etoposide. Current first\u2010line treatment is ineffective.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1049","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T11:40:09Z","timestamp":1732880409000},"page":"1215-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enteropathy\u2010associated T\u2010cell lymphoma: A population\u2010based cohort study on incidence, treatment, and outcome in the Netherlands"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-8182","authenticated-orcid":false,"given":"Frederik O.","family":"Meeuwes","sequence":"first","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Hematology Medisch Spectrum Twente  Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6014-4810","authenticated-orcid":false,"given":"Mirian","family":"Brink","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organization (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-9460","authenticated-orcid":false,"given":"Wouter J.","family":"Plattel","sequence":"additional","affiliation":[{"name":"Department of Hematology Medisch Spectrum Twente  Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-6256","authenticated-orcid":false,"given":"Joost S. P.","family":"Vermaat","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8904-3802","authenticated-orcid":false,"given":"Marie Jos\u00e9","family":"Kersten","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Center, Cancer Center Amsterdam University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00eblle","family":"Wondergem","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Center, Cancer Center Amsterdam University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-1817","authenticated-orcid":false,"given":"Otto","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Hematology Isala Hospital  Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-4150","authenticated-orcid":false,"given":"Marjolein W. 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