{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:42:11Z","timestamp":1758123731005,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited knowledge of the long\u2010term effects on the immune system after treatment for diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included DLBCL patients from the Danish Lymphoma Registry who obtained complete remission (CR) after (R)\u2010CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone)\u2010like immunochemotherapy. Each R<jats:sup>+<\/jats:sup> CHOP\u2010like treated patient was matched to five comparators from the Danish background population and furthermore compared to R<jats:sup>\u2212<\/jats:sup> CHOP\u2010like treated patients. Incidence rate ratios (IRRs) and risk differences (RDs) were calculated for a wide range of infections, autoimmune conditions, and immune deficiencies (AC\u2010IDs) combined and by subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>R<jats:sup>+<\/jats:sup> CHOP\u2010like treated patients had a higher risk of infections overall (IRR 1.5, 95% confidence interval [CI] 1.4\u20131.7: 10\u2010year RD 5.0%, 95% CI 2.2%\u20137.8%) and for a majority of the subtypes than matched comparators. Likewise, they had a higher risk of AC\u2010IDs overall (IRR 1.4, 95% CI 1.1\u20131.7; RD 0.8%, 95% CI 0.7%\u20132.2%) than matched comparators, however only of clinical relevance for three subtypes; autoimmune diseases of the endocrine system, sarcoidosis and immune deficiencies. The addition of rituximab to CHOP\u2010like therapy did not alter the incidence rates (IR) of infections overall (IRR 1.1, 95% CI 0.9\u20131.3) or AC\u2010IDs overall (IRR 0.8, 95% CI 0.5\u20131.3) compared to CHOP\u2010like therapy alone, although the IR for respiratory infections was significantly elevated (IRR 1.5, 95% CI 1.1\u20132.1). However, an increased use of IVIG treatment was observed among R<jats:sup>+<\/jats:sup> CHOP survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>R\u2010CHOP\u2010like treated patients face an increased risk of infections and AC\u2010IDs overall compared with the background population. The risk of infections and AC\u2010IDs did not change overall after the addition of rituximab to CHOP, however, an increased risk of respiratory infections is notable. These findings could highlight the need for expanded vigilance and prophylaxis strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1070","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T16:14:12Z","timestamp":1735402452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The long\u2010term risk of immune\u2010related conditions in survivors of diffuse large B\u2010cell lymphoma: A Danish nationwide registry study"],"prefix":"10.1002","volume":"6","author":[{"given":"Laura Schou","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja N\u00f8rholm","family":"Klausen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1006-4751","authenticated-orcid":false,"given":"Jonas Faartoft","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilis Danielsen","family":"Bacevi\u010dius","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"M\u00e9sz\u00e1ros J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-6708","authenticated-orcid":false,"given":"Thomas Stauffer","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Bj\u00f8rn","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Haematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Roost","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Haematology Vejle Sygehus  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schou Pedersen","sequence":"additional","affiliation":[{"name":"Department of Medicine G\u00f8dstrup sygehus  Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Ortved","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus","family":"Westermann","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Center of Rheumatic Research Aalborg (CERRA) Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salome","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Center of Rheumatic Research Aalborg (CERRA) Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene Wohlfahrt","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Center of 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