{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:06Z","timestamp":1753869426092,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>CD58 loss has been described as a mechanism of resistance to blinatumomab and chimeric antigen receptor T\u2010cell therapy, functioning as a modulator of response to T\u2010cell activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using flow cytometry, we evaluated the impact of CD58 mean fluorescence intensity (MFI) on the probability of achieving measurable residual disease (MRD) negativity in patients with B\u2010cell acute lymphoblastic leukemia treated with inotuzumab ozogamicin (InO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The odds ratio of achieving MRD negativity was 1.03 for every 1000 unit increase in CD58 MFI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that MRD negativity rates after InO are high, regardless of the intensity of CD58 expression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1076","type":"journal-article","created":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T06:38:37Z","timestamp":1735454317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD58 expression does not impact response to inotuzumab ozogamicin in patients with B\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9243-2662","authenticated-orcid":false,"given":"Rafael","family":"Madero\u2010Marroquin","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan W.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caner","family":"Saygin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam S.","family":"DuVall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Rahmani Youshanlouei","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clinton","family":"Osei","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology\/Oncology University of Chicago  Chicago Illinois 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JainN MayW MattisonRJ JonasB OluwoleO et\u00a0al.Acute lymphoblastic leukemia. National Comprehensive Cancer Guidelines. [Internet].2023. Available from:https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/all.pdf"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00353"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.1076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:33:07Z","timestamp":1741761187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.1076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jha2.1076"],"URL":"https:\/\/doi.org\/10.1002\/jha2.1076","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"2024-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1076"}}