{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:31:34Z","timestamp":1782883894534,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We assessed the impact of a prior malignancy diagnosis (PMD) \u2013 as a potential proxy for genetic cancer susceptibility \u2013 on the development of a second primary malignancy (SPM) and mortality in follicular lymphoma (FL) patients. From the nationwide Netherlands Cancer Registry, we selected all adult FL patients diagnosed in 1994\u20102012 (n\u00a0=\u00a08028) and PMDs and SPMs relative to FL, with follow\u2010up until 2017. We constructed two Fine and Gray models \u2013 with death as a competing risk \u2013 to assess the association between a PMD and SPM incidence. A PMD was associated with an increased incidence of SPMs (subdistribution hazard ratio [SHR], 1.30; 95% confidence interval [CI], 1.03\u20101.64) \u2013 especially carcinomas of the respiratory tract (SHR, 1.83; 95% CI, 1.10\u20103.05) and cutaneous squamous cell carcinomas (SHR, 1.58; 95% CI, 1.01\u20102.45) \u2013 and a higher risk of mortality in a multivariable model (HR, 1.43; 95% CI, 1.19\u20101.71). However, when additionally adjusted for the receipt of systemic therapy and\/or radiotherapy before FL diagnosis, only patients who received such therapies had an increased incidence of SPMs (SHR, 1.40; 95% CI, 1.02\u20101.93). In conclusion, patients with a PMD had a higher rate of SPMs and mortality than those without a PMD, which might have resulted from therapy\u2010related carcinogenesis.<\/jats:p>","DOI":"10.1002\/jha2.108","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T09:43:54Z","timestamp":1602150234000},"page":"489-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of prior malignancies on the development of second malignancies and survival in follicular lymphoma: A population\u2010based study"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-7897","authenticated-orcid":false,"given":"Manette A.W.","family":"Dinnessen","sequence":"first","affiliation":[{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht The 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