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The patient presented with somatosensory abnormalities in the extremities after local treatment of skin lesions and was diagnosed with CNS relapse of PC\u2010ALCL. Methotrexate, procarbazine, and vincristine therapy, and alternating brentuximab vedotin, followed by autologous hematopoietic stem cell transplantation (ASCT) cured the CNS lesions, whereas the skin lesions relapsed early. PC\u2010ALCL could relapse in the CNS; systemic chemotherapy and ASCT may be effective.<\/jats:p>","DOI":"10.1002\/jha2.1082","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T15:40:22Z","timestamp":1741707622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Central nervous system relapse of primary cutaneous anaplastic large cell lymphoma: A case report"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0059-5038","authenticated-orcid":false,"given":"Satoshi","family":"Mitsuyuki","sequence":"first","affiliation":[{"name":"Department of Hematology Sakai City Medical Center  Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Hematology Sakai City Medical Center  Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Hematology Sakai City Medical Center  Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Hematology Sakai City Medical Center  Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Yasuhara","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Sakai City Medical Center  Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sakai City Medical Center  Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology Sakai City Medical Center  Sakai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201011\u2010881268"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.280"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.12.3653"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.19.00581"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2010.04.004"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.14791\/btrt.2017.5.1.45"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(20)30366\u20105"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(15)00076\u20105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281457"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201010\u2010604561"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.01.003"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.1082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:56:34Z","timestamp":1745495794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.1082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/jha2.1082"],"URL":"https:\/\/doi.org\/10.1002\/jha2.1082","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"2024-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1082"}}