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Autophagic protein degradation is currently not targeted in myeloma treatment. This Phase I trial showed that the combination of the proteasome inhibitor carfilzomib and the autophagy inhibitor hydroxychloroquine was well tolerated in patients with relapsed\/refractory multiple myeloma. Adverse events were mostly Grades 1 and 2. An overall response rate of 44% indicates a meaningful clinical efficacy of this combination.<\/jats:p><jats:p><jats:bold>Trial Registration<\/jats:bold>: The study was registered at clinicaltrials.gov # NCT04163107.<\/jats:p>","DOI":"10.1002\/jha2.1091","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T14:34:34Z","timestamp":1737642874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combined Proteasome and Autophagy Inhibition in Relapsed\/Refractory Multiple Myeloma\u2014A Phase I Trial of Hydroxychloroquine, Carfilzomib, and Dexamethasone"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7488-4863","authenticated-orcid":false,"given":"Tobias S.","family":"Sl\u00f8rdahl","sequence":"first","affiliation":[{"name":"Department of Hematology St. Olavs Hospital  Trondheim Norway"},{"name":"Department of Clinical and Molecular Medicine 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