{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:38:10Z","timestamp":1783647490657,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Erythropoietic Protoporphyria (EPP) caused skin light sensitivity and liver cirrhosis in a 35\u2010year\u2010old patient who subsequently developed liver\u2010failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In absence of a human leukocyte antigens (HLA)\u2010matched\u2010unrelated donor, the father consented in donating for split liver transplantation (SLT) and allogeneic hematopoietic cell transplantation (HCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After bridging therapy and successful SLT a first paternal HCT resulted in graft failure. For a second haploidentical HCT a different regimen was applied leading to engraftment while protoporphyrin (PP) blood\u2010levels decreased to normal and skin light sensitivity skin disappeared, leading to complete remission in an immunosuppressive\u2010free patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Haploidentical transplantation is a feasible treatment approach in EPP\u2010patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>The authors have confirmed clinical trial registration is not needed for this submission<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1092","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T12:30:02Z","timestamp":1739881802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paternal Split\u2010Liver Transplantation Followed by Haploidentical Hematopoietic Cell Transplantation in an Adult Patient With Protoporphyria\u2010Induced Liver Failure"],"prefix":"10.1002","volume":"6","author":[{"given":"Ulrich","family":"St\u00f6lzel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II and Porphyria Center Klinikum Chemnitz  Chemnitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1306-6639","authenticated-orcid":false,"given":"Lasse","family":"Jost","sequence":"additional","affiliation":[{"name":"Division of Stem Cell Transplantation and Cellular Immunotherapies Department of Internal Medicine II University Hospital Schleswig Holstein Kiel, Kiel University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Seehofer","sequence":"additional","affiliation":[{"name":"Department of Visceral Transplantation, Vascular and Thoracic Surgery University Hospital of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-4335","authenticated-orcid":false,"given":"Katharina","family":"Egger\u2010Heidrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus, TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Scheuermann","sequence":"additional","affiliation":[{"name":"Department of Visceral Transplantation, Vascular and Thoracic Surgery University Hospital of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"H\u00f6lig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus, TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stauch","sequence":"additional","affiliation":[{"name":"Deutsches Kompetenz\u2010Zentrum f\u00fcr Porphyriediagnostik und Konsultation MVZ Labor Volkmann und Kollegen GbR  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Kunadt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus, TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Schuppan","sequence":"additional","affiliation":[{"name":"Institute of Translational Immunology Johannes Gutenberg University Mainz  Mainz Germany"},{"name":"Division of Gastroenterology Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schetelig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus, TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Wohmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II and Porphyria Center Klinikum Chemnitz  Chemnitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bornh\u00e4user","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus, TU Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"St\u00f6lzel","sequence":"additional","affiliation":[{"name":"Division of Stem Cell Transplantation and Cellular Immunotherapies Department of Internal Medicine II University Hospital Schleswig Holstein Kiel, Kiel University  Kiel Germany"},{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus, TU Dresden  Dresden 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